Clinical trial · Interventional
Comparative Study of Chemoradiation and Sequential Chemoradiation About Lung Adenocarcinoma Patients With Postoperative in pN2
NCT02132143CI-TRIAL-00017821unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study compares chemoradiation and sequential chemoradiation about Lung adenocarcinoma patients with postoperative in pN2 and then determines which therapeutic method is better for the patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Adenocarcinoma Patients With Postoperative in pN2 | Lung Adenocarcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| intensity-modulated radiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Progression-free survival&Concurrent chemoradiotherapy
- description
- The first day of radiotherapy given pemetrexed(Powder for Injection) 500mg/m2 + cisplatin(Powder for Injection) 75mg/m2, two cycles of chemotherapy given during radiotherapy; then continue to give two cycles of consolidation chemotherapy, 21 days as a cycle. Intensity-modulated radiation therapy(IMRT),5000cGy~6000cGy/5~6W.
- interventionNames
- Radiation: intensity-modulated radiation
- type
- ACTIVE_COMPARATOR
- label
- Progression-free survival&sequential chemoradiotherapy
- description
- Patients received adjuvant chemotherapy for four cycles,pemetrexed(Powder for Injection) 500mg/m2 + cisplatin(Powder for Injection) 75mg/m2, 21 days as a cycle.Then accept the Intensity-modulated radiation therapy(IMRT),5000cGy~6000cGy/5~6W.
- interventionNames
- Radiation: intensity-modulated radiation
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of Lung adenocarcinoma * Postoperative staging pN2 period * Voluntary participation and informed consent * Age ≥ 18 years old, male or female, within six months of weight loss of less than 10%, can tolerate radiotherapy * performance status( PS) score 0-2. * Hemoglobin ≥ 80 g / L, white blood cell ≥ 4 × 109 / L, platelets ≥ 100 × 109 / L. * Liver function: alanine aminotransferase (ALAT), aspartate transaminase (ASAT) \<upper limit of normal (ULN) of 1.5 times, bilirubin \<1.5 × ULN. * Renal function: serum creatinine \<1.5 × ULN. * Compliance, and can be regular follow-up, voluntary compliance with study requirements Exclusion Criteria: * Do not meet the inclusion criteria * There is evidence of distant metastases * Suffered from other malignancies in five years * Within the past January subjects received other drug trials * Having serious allergies or idiosyncratic persons, such as you can not use folic acid, dexamethasone, vitamin B12 patients * Severe lung or heart disease, a history * Refuses or is unable to sign informed consent to participate in trials * The abuse of drugs or alcohol addicts. * Patients with difficult to control bacterial, viral, fungal infections * Having a personality or mental disorders, without civil capacity or restricted civil capacity. * Being pregnant or lactating women.
References
Publications (0)
Data not yet available
No reference posted for this study.