Clinical trial · Interventional
Dose-Guided Radiotherapy in Oesophageal Cancer: Managing the Real Dose
Managing the Real Dose: Evaluating the Impact on Gastric Filling on the Delivered Radiation Dose in Gastrooesophageal Junction Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will prospectively collect patients undergoing the standard CROSS regimen in the neoadjuvant setting of the treatment for gastro-oesophageal cancer. The investigators will focus on the potential geometric differences between the OAR and target volume on the initial planning CT and on the kilovolt (kV) cone-beam computed tomography (CBCT). They expect a potential difference in the abdominal part of the planned target volume (PTV) and/or gastro-oesophageal junction part. Furthermore, the impact of gastric filling , potential tumor regression and the accuracy of 5 mm PTV margin in the thoracic PTV will be monitored.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenocarcinoma | Adenocarcinoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| with feeding/fluid instruction | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- without feeding/fluid instructicon
- description
- Ten patients treated with preoperative chemoradiotherapy without feeding/fluid instructions
- type
- EXPERIMENTAL
- label
- with feeding/fluid instructions
- description
- Ten patients treated with preoperative chemoradiotherapy with feeding/fluid instructions
- interventionNames
- Other: with feeding/fluid instruction
Primary outcomes (1)
- measure
- Proportion of patients in which the CTV was not covered
- timeFrame
- Weekly during radio-and chemotherapy (5 weeks)
- description
- Proportion of patients in which the CTV was not covered (CTV D99, V95, Dmean) with and without different filling status of the stomach in patients treated with neoadjuvant chemoradiotherapy for gastroesophageal cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically proven adenocarcinoma of the gastro-oesophageal junction * Age 18 years or older * International Union Against Cancer (UICC) T2-4 N0-2 M0, potentially resectable disease treated by the CROSS regimen * WHO 0-2 Exclusion Criteria: * Thoracic adenocarcinoma/squamous cell carcinoma * Palliative treatment for the oesophageal cancer
References
Publications (0)
Data not yet available