Clinical trial · Observational
Vascular Function and Uterine Fibroids
Sympathetic Nerve Activity and Vascular Function in Women With Uterine Leiomyomata
NCT02123069CI-TRIAL-00031897completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to learn how uterine fibroids may be connected to heart disease and high blood pressure. It is not known what causes fibroids, but they frequently occur in women who also have high blood pressure, heart disease, and stroke. The investigators of this study want to learn if certain changes in the blood vessels or nerve activity can put women at risk for these diseases and for fibroids.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leiomyoma | Leiomyoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Acetylcholine | Drug | — | UNRESOLVED |
| Brachial artery catheter | Device | — | UNRESOLVED |
| Nitroprusside | Drug | — | UNRESOLVED |
| Nitroprusside and phenylephrine | Drug | — | UNRESOLVED |
| Norepinephrine | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Women with uterine fibroids
- description
- * Brachial artery catheter * Acetylcholine * Nitroprusside * Norepinephrine * Nitroprusside and phenylephrine
- interventionNames
- Device: Brachial artery catheter
- Drug: Acetylcholine
- Drug: Nitroprusside
- Drug: Norepinephrine
- Drug: Nitroprusside and phenylephrine
- label
- Women without uterine fibroids
- description
- * Brachial artery catheter * Acetylcholine * Nitroprusside * Norepinephrine * Nitroprusside and phenylephrine
- interventionNames
- Device: Brachial artery catheter
- Drug: Acetylcholine
- Drug: Nitroprusside
- Drug: Norepinephrine
- Drug: Nitroprusside and phenylephrine
Primary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 25 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Women 25-50 years old * Premenopausal Exclusion Criteria: * Postmenopausal * Pregnant or currently breastfeeding * Using blood pressure medications or anti-depression medications * High blood pressure * Diabetes * Disease in the kidneys, lungs, or blood vessels * Chronic diseases (for example: Crohn's disease, rheumatoid arthritis, bipolar mood disorder, etc.) * Smoker * High cholesterol * BMI higher than 30
References
Publications (0)
Data not yet available
No reference posted for this study.