Clinical trial · Interventional
Full Spectrum vs. Standard Forward-viewing Colonoscopy
Full Spectrum vs. Standard Forward-viewing Colonoscopy With and Without Right-colon Retroflexion: a Randomized, Bicentric Back-to-back Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to evaluate FUSE-colonoscopy in terms of feasibility and its possible additive contribution in the detection of important lesions, namely polyps and cancers, compared to the standard "forward-viewing" approach, with and without the addition of the right-colon retroflexion technique, in a series of patients undergoing back-to-back screening or surveillance colonoscopies in a randomized fashion.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Neoplasms | Colon Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| full-spectrum colonoscopy | Procedure | — | UNRESOLVED |
| right colon retroflexion | Procedure | — | UNRESOLVED |
| standard forward-viewing colonoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- standard forward-viewing colonoscopy
- description
- polyp detection with standard forward-viewing colonoscopy polyp detection in the right colon with scope retroflexion
- interventionNames
- Procedure: standard forward-viewing colonoscopy
- Procedure: full-spectrum colonoscopy
- Procedure: right colon retroflexion
- type
- ACTIVE_COMPARATOR
- label
- full-spectrum colonoscopy
- description
- polyp detection with full-spectrum colonoscopy polyp detection in the right colon with scope retroflexion
- interventionNames
- Procedure: standard forward-viewing colonoscopy
- Procedure: full-spectrum colonoscopy
- Procedure: right colon retroflexion
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * adults undergoing elective screening or surveillance colonoscopy * symptomatic adults with indication for colonoscopy Exclusion Criteria: * age over 80 years * poor overall health (ASA III, IV) * recent abdominal surgery * presence of abdominal wall hernias * active colitis * multiple right colon diverticula * previous bowel resection * inflammatory bowel disease * polyposis syndromes
References
Publications (3)
- BACKGROUNDHewett DG, Rex DK. Miss rate of right-sided colon examination during colonoscopy defined by retroflexion: an observational study. Gastrointest Endosc. 2011 Aug;74(2):246-52. doi: 10.1016/j.gie.2011.04.005. Epub 2011 Jun 15. PMID 21679946
- BACKGROUNDGralnek IM, Segol O, Suissa A, Siersema PD, Carr-Locke DL, Halpern Z, Santo E, Domanov S. A prospective cohort study evaluating a novel colonoscopy platform featuring full-spectrum endoscopy. Endoscopy. 2013 Sep;45(9):697-702. doi: 10.1055/s-0033-1344395. Epub 2013 Aug 12. PMID 23939509
- DERIVEDPapanikolaou IS, Apostolopoulos P, Tziatzios G, Vlachou E, Sioulas AD, Polymeros D, Karameris A, Panayiotides I, Alexandrakis G, Dimitriadis GD, Triantafyllou K. Lower adenoma miss rate with FUSE vs. conventional colonoscopy with proximal retroflexion: a randomized back-to-back trial. Endoscopy. 2017 May;49(5):468-475. doi: 10.1055/s-0042-124415. Epub 2017 Jan 20. PMID 28107765