Clinical trial · Interventional
Yogic Breathing Changes Salivary Components
Induction of Salivary Neuromodulators by Chanting and Breathing Exercise
NCT02108769CI-TRIAL-00014210completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Our aim is to analyze two ancient Tamil practices (chanting and breathing exercise) if they are capable of stimulating saliva containing agents that can be beneficial to the nervous system. Our study subjects will perform Tamil chanting and Tamil breathing exercise. Saliva will be collected before, during and after the exercises. We will quantify the specific proteins in these salivary samples. The results will benefit further studies in various patient populations.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Alzheimer Disease | — | UNRESOLVED | — |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Neurodegenerative Diseases | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Attention Control | Behavioral | — | UNRESOLVED |
| Yogic Breathing | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Yogic Breathing
- description
- 1. Chanting Om 1. Sharp deep inhalation through nostrils 2. Slow exhalation through mouth while chanting Om. At this step the subjects will perform a slow and complete exhalation. Repeat for 10 min. During the whole period of chanting, the subjects keep their eyes closed. 2. Yogic Breathing: 1. Check which of the two nostrils exhibit free flow of air. For the explanation purpose the nostril with free flow of air is treated as Nostril 1 and the other one as Nostril 2. 2. Close Nostril 2 and inhale a sharp deep breath through Nostril 1 and then close both the nostrils so no inhaled air escapes. Air should not escape through mouth either. This inhalation step should take about 4 seconds. 3. Hold breath in this position for about 16 seconds. 4. Open Nostril 2 and exhale for about 8 seconds. Complete exhalation is required. Abdomen will slowly curve-in as the subject exhales. This is normal and encouraged. No air should leak through the Nostril 1 or mouth. 5. Go to step a).
- interventionNames
- Behavioral: Yogic Breathing
- type
- ACTIVE_COMPARATOR
- label
- Attention Control
- description
- The participants will read a text of their choice for 20 minutes.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Anyone Exclusion Criteria: * breathing problems (inability to breath through nostrils, chronic bronchitis, emphysema and asthma) * speech problems that would prevent chanting * inability to listen and follow exercise instructions * sinus congestion * Sjogren's syndrome * chronic dry mouth due to medication or other conditions * use of anti-cholinergic medications Informed consent will be obtained from each subject after completely describing the study.
References
Publications (5)
- BACKGROUNDAloe L, Rocco ML, Bianchi P, Manni L. Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med. 2012 Nov 29;10:239. doi: 10.1186/1479-5876-10-239. PMID 23190582
- BACKGROUNDKumar S, Nagendra H, Manjunath N, Naveen K, Telles S. Meditation on OM: Relevance from ancient texts and contemporary science. Int J Yoga. 2010 Jan;3(1):2-5. doi: 10.4103/0973-6131.66771. PMID 20948894
- BACKGROUNDRajasekaran R, Narayana A. Thirumular--pioneer of the immunology concept. Bull Indian Inst Hist Med Hyderabad. 2006 Jul-Dec;36(2):129-44. PMID 18175648
- DERIVEDTwal WO, Wahlquist AE, Balasubramanian S. Yogic breathing when compared to attention control reduces the levels of pro-inflammatory biomarkers in saliva: a pilot randomized controlled trial. BMC Complement Altern Med. 2016 Aug 18;16:294. doi: 10.1186/s12906-016-1286-7. PMID 27538513
- DERIVEDBalasubramanian S, Janech MG, Warren GW. Alterations in Salivary Proteome following Single Twenty-Minute Session of Yogic Breathing. Evid Based Complement Alternat Med. 2015;2015:376029. doi: 10.1155/2015/376029. Epub 2015 Mar 19. PMID 25873979