Photodynamic Therapy During Surgery in Treating Patients With Pleural Malignancy

Inclusion Criteria:

* Histological diagnosis of NSCLC or MPM; pts must have clinical and/or pathological evidence of pleural spread or stage III/IV MPM
* Pts with NSCLC who have received, are receiving or are planning to receive two to four cycles of standard frontline chemotherapy are eligible; choice of chemotherapy is at the discretion of the medical oncologist; concurrent chemoradiotherapy will not be permitted during the active study period; post-operative radiotherapy can be administered as clinically indicated
* Assessment by the attending thoracic surgeon that the primary tumor is resectable in pts with NSCLC and pleural spread; tumor will be deemed resectable if there is no extension through fascia, no bony chest or vertebral body involvement, and no radiographic evidence of mediastinal involvement
* Assessment by the attending thoracic surgeon that radical pleurectomy can be safely achieved in pts with malignant pleural mesothelioma
* All studies required for evaluation will be performed within 8 weeks of Photofrin administration
* Pts of all ethnic and gender groups will be included; protocol accrual will be reviewed annually to include a determination of minority and gender representation; if accrual demonstrates under-representation of any group with comparison to disease incidence in that group, then appropriate measures will be undertaken to attempt to increase participation of pts of that minority or gender group
* ELIGIBILITY CRITERIA FOR HISTORICAL CONTROL POPULATION
* Pts undergoing extrapleural pneumonectomy without PDT for MPM or stage IV (M1A) NSCLC (after American Joint Committee on Cancer \[AJCC\] staging change 2010) or stage IIIB (before staging change) with malignant pleural effusion treated at Ohio State University (OSU) from 2005-2012
* Historical control data will be derived from patient medical records at the Ohio State University Medical Center (OSUMC)

Exclusion Criteria:

* Pts who have grade III-IV elevations in liver transaminases (as defined by the Common Terminology Criteria for Adverse Events \[CTCAE\] version \[v.\] 4.0) or a bilirubin in excess of 1.5 mg/dl
* Pts who are medically unfit to tolerate surgery
* Pts with known human immunodeficiency virus (HIV) or hepatitis C virus (HCV) disease (routine testing is not needed if not clinical indicated)
* Pregnant or lactating pts
* Prior treatment for NSCLC except for pleurodesis and/or standard frontline chemotherapy
* Pts who have received prior mantle or extensive mediastinal radiation