A Study to Assess the Efficacy and Safety of Eltrombopag as a Rescue of Isolated Chemotherapy-induced Thrombocytopenia

Inclusion Criteria:

* Subjects aged ≥18 years
* Diagnosed with solid tumor
* On active chemotherapy with combined regimen
* A baseline platelet count of \<75,000/μL within 2 days of screening
* Hb ≧ 9.0 g/dL
* ANC ≧ 1,500/uL
* GOT and GPT ≤ 3 x ULN
* Serum bilirubin ≤ 1.5 x ULN
* Albumin ≥ 2.5 g/dL
* Adequate renal function for chemotherapy:

serum creatinine ≤ 1.5 × ULN (CTCAE Grade 1).

* Be able to take oral medicine
* ECOG performance ≤ 2
* Has a negative urine or serum pregnancy test at screening and is willing to use contraceptive measures during medication of this trial (Non-childbearing potential is defined as hysterectomy, bilateral oophorectomy, bilateral salpingectomy, tubal ligation and post-menopausal status) for patients with childbearing potential
* Ability to participate and willingness to give written informed consent and to comply with the study restrictions

Exclusion Criteria:

* Single agent chemotherapy or not having chemotherapy
* Serious cardiac, cerebrovascular, or pulmonary disease that, in the opinion of the investigator, would preclude trial medication
* Severe GI tract obstruction that require continuous NG decompression
* Subjects with hemoglobinopathies, e.g. sickle cell anaemia, thalassemia major
* Any prior history of arterial or venous thrombosis
* Any disease condition associated with active bleeding or requiring anticoagulation, heparin or warfarin
* Pre-existing cardiac disease (congestive heart failure New York Heart Association (NYHA) Grade III/IV), (See Appendix 1), or arrhythmias known to involve the risk of thromboembolic events (e.g. atrial fibrillation), or subjects with a QTc \>450 msec.
* Seizure disorder that has not been well controlled
* Pregnant or nursing women
* Thyroid dysfunction not adequately controlled.
* Within 2months prior to entering the study, been received radiotherapy to more than 20% bone marrow bearing sites.
* Administration of an investigational drug within 30 days or 5 half-lives, whichever is longer, preceding the first dose of investigational product in the study. Concurrent participation in another interventional clinical trial or administration of any investigational drug during the study is also not permitted.
* A known immediate or delayed hypersensitivity reaction or idiosyncrasy that, in the opinion of the Investigator is due to drugs chemically related to eltrombopag
* Subjects taking anti-neoplastic and immunomodulatory medications (this includes mycophenolate mofetil, thymosine alpha, and extended courses of supraphysiologic doses of steroids)