Clinical trial · Interventional
2D vs 3D Planning for High-Dose Rate (HDR) Gynecological Brachytherapy
Clinical and Dosimetric Comparison of 2D Versus 3D HDR Brachytherapy
NCT02091050CI-TRIAL-00034670completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Demonstrate the limitations of conventional dosimetry (2D) for the adjuvant brachytherapy treatment and assess whether tridimensional dosimetry relates more faithfully with the occurrence of adverse effects.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervix Cancer | — | UNRESOLVED | — |
| Endometrial Cancer | Malignant Endometrial Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 2D HDR planning | Other | — | UNRESOLVED |
| 3D HDR planning | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- HDR Brachytherapy 24Gy (4 x 6Gy)
- description
- Vaginal vault brachytherapy, associated or not with external beam radiotherapy.
- interventionNames
- Other: 2D HDR planning
- Other: 3D HDR planning
Primary outcomes (1)
- measure
- Dosimetry of Organs of genitourinary and gastrointestinal tracts
- timeFrame
- one week after the tomograph
- description
- Dose in bladder; rectum; small intestine; sigmoid colon; urethra; dose trigone; vaginal cuff.
Secondary outcomes (5)
- measure
- Cost analysis with local care.
- timeFrame
- 6 weeks
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * Malignant neoplasm of the cervix or endometrium; * Tomography scan available in the planning system. Exclusion Criteria: * Patients did not undergo surgery as initial treatment; * Patients without available tomography for planning;
References
Publications (1)
- RESULTSapienza LG, Flosi A, Aiza A, de Assis Pellizzon AC, Chojniak R, Baiocchi G. Volumetric (3D) bladder dose parameters are more reproducible than point (2D) dose parameters in vaginal vault high-dose-rate brachytherapy. Sci Rep. 2016 Jun 14;6:28074. doi: 10.1038/srep28074. PMID 27296459