Clinical trial · Observational
CT Perfusion Changes in GI Cancer During Adenosine Vasodilation Test
Abdominal Tissue Perfusion Changes in Esophageal and Gastric Cancer During Adenosine Vasodilation Measured With Computed Tomography (CT) Perfusion
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study was to investigate changes in abdominal tissue perfusion during adenosine vasodilation. Our hypotheses were that CT perfusion measurements are altered by changes in the circulatory system mediated by adenosine, and a more differentiated assessment of the circulatory capacity of abdominal tumours could be achieved by sequential rest and adenosine vasodilation CT perfusion measurements.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Adenosine Vasodilation test
- description
- Group scanned with CT perfusion during adenosine vasodilation test.
- label
- Reference group
- description
- Group scanned twice without adenosine vasodilation test for a reference. No randomization.
Primary outcomes (1)
- measure
- Change in arterial flow during adenosine vasodilation test (CT perfusion parameter)
- timeFrame
- 0 min and 15 min
Secondary outcomes (5)
- measure
- Change in Blood pressure during adenosine vasodilation test
- timeFrame
- 0 min and 15 min
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Tumour larger than 1.5 cm on diagnostic CT * Normal serum creatinine * Age above 18 * Informed written and oral consent. Exclusion Criteria: * Contrast allergy or contrast induced nephropathy * BMI \> 40 * Asthma or Chronic Obstructive Lung Disease * Heart failure (NYHA III+) * Heart conduction disorder * Atrial fibrillation * 2nd/3rd Heart block * Long QT syndrome * Wolf Parkinson White Syndrome * Moderate / severe aortic stenosis * Haemodynamic contraindications for adenosine, systolic pressure below 90
References
Publications (0)
Data not yet available