Clinical trial · Interventional
Evaluation of Injection Techniques in Celiac Plexus Neurolysis
Evaluation of Injection Techniques in Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis (EUS-CPN)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
1\. To evaluate the efficacy of EUS-CPN in subjects who experience a sympathetic response during injection when compared with subjects who do not experience sympathetic response during injection. EUS-CPN when performed in subjects who experience a sympathetic response during injection will have better pain relief when compared to subjects who do not experience a sympathetic response during injection.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pain | — | UNRESOLVED | — |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| no sympathetic response | Other | — | UNRESOLVED |
| Sympathetic response | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- sympathetic response
- description
- This group will be composed of subjects who experience a heart rate and/or Blood Pressure change during injection.
- interventionNames
- Other: Sympathetic response
- type
- OTHER
- label
- no sympathetic response
- description
- This group will be made up of subjects that do not experience a vital sign change with injection for CPN.
- interventionNames
- Other: no sympathetic response
Primary outcomes (1)
- measure
- abdominal pain
- timeFrame
- within the first year post CPN
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 89 Years
Show eligibility criteria text
Inclusion Criteria: 1. Abdominal pain typical for pancreatic cancer ( pain score ≥ 3/10) 2. Abdominal CT consistent with diagnosis of pancreatic cancer 3. Pancreatic cancer confirmed by EUS-FNA 4. Inoperable pancreatic cancer as determined during EUS or prior CT Exclusion Criteria: 1. Age under 19 years 2. Unable to safely undergo EUS for any reason 3. Coagulopathy (Prothrombin time \> 18 secs, platelet count \< 80,000/ml) 4. Previous CPN or other neurolytic block that could affect pancreatic cancer-related pain or had implanted epidural or intrathecal analgesic therapy 5. Another cause for abdominal pain such as pseudocyst, ulcer or other intrabdominal disorder 6. Noncompliance such that the patient would not return for subsequent follow-up 7. Active alcohol or other drug use or significant psychiatric illness 8. Unable to consent 9. Non-English speaking
References
Publications (0)
Data not yet available