Clinical trial · Interventional
Contrast Enhanced Ultrasound and Shear Wave Elastography in Measuring Response in Patients With Breast Cancer Receiving Chemotherapy Before Surgery
Real Time Contrast Enhanced Ultrasound and Ultrasound-Based Elastography: Novel Techniques in Assessment of Treatment Response to Neoadjuvant Chemotherapy for Breast Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Slow accrual
Summary
Brief summary (as posted)
This pilot clinical trial studies contrast enhanced ultrasound and shear wave elastography in measuring response in patients with breast cancer receiving chemotherapy before surgery. New imaging procedures, such as contrast enhanced ultrasound and shear wave elastography, may predict treatment response earlier and more accurately than contrast enhanced magnetic resonance imaging.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Definity, (Lipid Microspheres) Intravenous Suspension | Drug | — | UNRESOLVED |
| dynamic contrast-enhanced ultrasound imaging | Procedure | — | UNRESOLVED |
| Philips Shear Wave Elastography | Device | — | UNRESOLVED |
| shear wave elastography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic (CEUS, SWE)
- description
- Patients undergo dynamic contrast-enhanced ultrasound imaging and shear wave elastography at baseline, 2-3 weeks after initiation of chemotherapy, and before surgery.
- interventionNames
- Procedure: dynamic contrast-enhanced ultrasound imaging
- Procedure: shear wave elastography
- Drug: Definity, (Lipid Microspheres) Intravenous Suspension
- Device: Philips Shear Wave Elastography
Primary outcomes (2)
- measure
- Model predicted treatment response for CEUS and SWE
- timeFrame
- Up to 1 year
- description
- Weighted Kappa will be used to assess the agreement.
- measure
- Pathologically determined treatment response for CEUS and SWE
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Women with histologically confirmed breast cancer (by core needle biopsy) * Women with \>= 2 cm clinically or radiologically measureable breast cancer * Women scheduled to receive neoadjuvant chemotherapy as part of their treatment plan * Women competent to sign study specific written Informed Consent * Women willing to comply with protocol requirements Exclusion Criteria: * Women who are pregnant * Women who have undergone open surgical (excisional) biopsy for breast cancer diagnosis * Women who have had a prior history of breast cancer in the same breast * Women with known cardiac shunt, pulmonary hypertension or hypersensitivity to perflutren agent * Women who cannot consent for themselves
References
Publications (0)
Data not yet available