Benefits and Tolerance of Exercise in Patients With Generalized and Stabilized Myasthenia Gravis

Inclusion Criteria:

1. Patient with generalized MG of stage II or III according to the MGFA classification, stabilized for at least 6 months. Criteria for MG are either

   * positive dosage of ant-RACh or MuSK auto-antibodies;
   * If absent, myasthenic symptoms decrement\> 10% in EMNG and test the positive prostigmine
2. Patient ≥ 18 and ≤ 70 years old
3. Patient having an health insurance
4. Informed written consent

Exclusion Criteria:

1. Patients under particular protection
2. Enrolment in another biomedical research in the last 3 months;
3. Patients for whom physical practice is contra-indicated because of :

   * Unstable coronary Syndrome or myocardial infarction within the past 3 months
   * Heart failure with systolic ejection fraction \< 50 %
   * Respiratory failure defined by a vital capacity (CV) \< 70 %
   * Stroke
   * Other neuromuscular pathology
   * Disabling Rheumatologic disease (\> 80 % disability according to the Barthel scale)
   * Chronic Pain or disabling orthopaedic conditions
   * Hospitalization in the last 3 months for a serious medical or surgical condition
   * Anemia (hematocrit \< 30%)
4. MGFA grade I, grade IV or V
5. Severe cognitive impairment
6. MGQOL-15 below 15/60