Clinical trial · Observational
Impact of Diverticular Disease on the Detection of Colon Adenomas
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Benign adenomas of the colon have the potential to degenerate and become malignant. Therefore adenomatous polyps should be detected and resected during colonoscopy. Factors like advanced age and male gender are associated with the detection of adenomas. The same epidemiological pattern can be found with regard to colon diverticula. Furthermore, western world countries report higher incidences of both colorectal carcinoma as well as diverticular disease. It is not known whether a correlation exists between both entities. Some recent data have postulated higher adenoma detection rates in patients with concomitant diverticular disease (Rondagh EJ et al. Eur J Gastroenterol Hepatol. 2011; 23:1050-5. Kieff BJ et al. Am J Gastroenterol 2004; 99: 2007-11). If a positive correlation could be found this would possibly affect recommendations regarding colonoscopy surveillance intervals for patients with and without diverticular disease. The investigators therefore plan to conduct the following trial.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Adenoma | Colon Adenoma | ONTOLOGY_EXACT | 0.98 |
| Diverticulosis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Routine colonoscopy
- description
- Patients receiving routine colonoscopy (for a multitude of indications) at the study centers are eligible for participation
Primary outcomes (1)
- measure
- Adenoma detection rate
- timeFrame
- up to 2 weeks (participants will be followed for the duration of hospital stay or outpatient treatment, an expected average of 2 weeks)
- description
- After obtaining the histopathological diagnosis of resected polyps (approximately 3 days - 2 weeks after colonoscopy ) accuracy of optical diagnosis can be determined
Secondary outcomes (2)
- measure
- Polyp detection rate
- timeFrame
- up to one day
- description
- a maximum of one day is expected for colonoscopy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * indication for colonoscopy * age \>= 18 years Exclusion Criteria: * pregnant women * patients denying written consent * indication for colonoscopy: familial adenomatous polypose * indication for colonoscopy: inflammatory bowel disease * indication for colonoscopy: previously known colon polyp/adenoma/carcinoma * history of colon surgery * contraindication for resection of polyps * American Society of Anesthesiologists (ASA) class IV, V or VI
References
Publications (0)
Data not yet available