Clinical trial · Interventional
EDICT - Exercise inDuced Changes In Colorectal Cancer Tissues
Clinical and Biological Effects of a Preoperative Exercise Programme in Colorectal Tumour and Skeletal Muscle Tissues (Exercise inDuced Changes In Colorectal Cancer Tissues)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot study looks to explore the biological effects of exercise on cancer and muscle cells using a two week exercise program (HIThigh intensity training) on 20 patients with newly diagnosed and operable colorectal cancer following diagnosis and prior to surgery. Maximal oxygen uptake will also be measured. The aim of this pilot is to assess the feasibility of recruiting participants to and carrying out a two week preoperative exercise program in patients with colorectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise programme | Procedure | — | UNRESOLVED |
| Muscle biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Exercise programme
- description
- Exercise programme Muscle biopsies
- interventionNames
- Procedure: Exercise programme
- Procedure: Muscle biopsy
Primary outcomes (1)
- measure
- Assess the feasibility of carrying out a two week preoperative exercise program in patients with colorectal cancer and assess the effects of preoperative exercise on the proliferation of colorectal cancer cells
- timeFrame
- 1 year
- description
- To assess the feasibility of carrying out a two week preoperative exercise program in patients with colorectal cancer and to assess the effects of preoperative exercise on the proliferation of colorectal cancer cells by measuring the change in the percentage of cells staining positive for Ki67 (a measure of cell proliferation).
Secondary outcomes (11)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Colorectal cancer confirmed by histology * Considered fit for surgery by surgical and anaesthetic team * Considered fit for physical activity programme by MDT * Age ≥ 18 years * BMI ≥ 26 kg/m2 * Not pregnant * Non obstructing cancer * Able to provide written informed consent * Patients not having neoadjuvant chemotherapy Exclusion Criteria: * Receiving hormone therapy * Patients with diabetes * Patients currently on either a dietary or exercise programme reflective of the World Cancer Research Fund Guidelines. * Cardiac or renal impairment * Excessive use of laxatives * History of eating disorders * Patients with inflammatory bowel disorders/coeliac * Strong family history/polyposis (i.e. more than one 1st degree relative \<55yrs) * Patients with previous or concurrent malignancies
References
Publications (0)
Data not yet available