Study of I-125 Brachytherapy Versus Intensity-modulated Radiation Therapy to Treat Inoperable Salivary Gland Cancer

Inclusion Criteria:

* Patients are diagnosed histologically as primary or recurrent salivary gland cancers that may occur in either major salivary glands or minor salivary glands.
* The inoperable circumstance include: Primary or recurrent salivary gland cancers that could not be resected completely or could not get negative incision.
* T3/T4 tumor patients with severe medical comorbidities could not accept the high risk of perioperative complications.
* At least one measurable tumor or focus (according to RESIST 1.1 Standard).
* Karnofsky score\> 60.
* Survival time predicted ≥ 3months;
* HGB≥9 g/dL, WBC≥3.0×10\^9/L, NEUT≥1.5×10\^9/L, platelet count (PLT)≥ 100×10\^9/L; TBIL≤1.5 upper limit of normal, Alanine aminotransferase (ALT)/AST≤3 upper limit of normal; Cera≤1.5 upper limit of normal.
* Male or female with fertility in the experiment are willing to take contraceptive measures.

Exclusion Criteria:

* Radioactive therapy history of head and neck.
* Suffering from other malignant tumor in recent five years, except skin basal cell carcinoma or carcinoma in situs of cervix.
* Chemotherapy history.
* Receiving other effective therapy.
* Distant metastases.
* Pathologic result as squamous cell carcinoma.
* Neurological or mental abnormalities which affect cognitive ability.
* Severe cardiovascular and cerebrovascular diseases, such as heart failure (NYHA III-IV class), uncontrolled coronary heart disease, cardiomyopathy, uncontrolled arrhythmias, uncontrolled hypertension, myocardial infarction or cerebral infarction within past six months.
* Active serious clinical infections :\> Class 2 NCI-Common Toxicity Criteria for Adverse Effects (CTCAE) Version 4.0 within 14 days before randomization, including active tuberculosis.
* HIV infection or active hepatitis B or hepatitis C.
* Uncontrolled systemic diseases, such as poorly controlled diabetes mellitus.
* Medical history of interstitial lung disease, such as interstitial pneumonia, pulmonary fibrosis, or baseline chest X-ray / CT showed evidence of interstitial lung disease;
* Pregnancy (via urine β-human chorionic gonadotropin test to determine) or breastfeeding.