Clinical trial · Interventional
Misoprostol for Second Trimester Termination of Pregnancy
A Comparison Between Vaginal Misoprostol vs. Buccal Misoprostol For Second Trimester Termination of Pregnancy
NCT02048098CI-TRIAL-00016637completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare the efficacy of 400 µg vaginal misoprostol per 3 hours to 400 µg buccal misoprostol per 3 hours in second trimester termination of viable pregnancy
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Abortion, Induced | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Buccal misoprostol | Drug | — | UNRESOLVED |
| Vaginal misoprostol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Buccal misoprostol
- description
- 400 µg buccal misoprostol per 3 hours
- interventionNames
- Drug: Buccal misoprostol
- type
- ACTIVE_COMPARATOR
- label
- vaginal misoprostol
- description
- 400 µg vaginal misoprostol per 3 hours
- interventionNames
- Drug: Vaginal misoprostol
Primary outcomes (1)
- measure
- Induction to fetal expulsion interval
- timeFrame
- 15 minutes after fetus delivered
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 16 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * gestational age between 12-24 weeks * live fetus * singleton pregnancy * Bishop score \<5 * no uterine contraction Exclusion Criteria: * prostaglandin allergy * a scar in uterus * uterine abnormality * premature rupture of membranes
References
Publications (1)
- DERIVEDAl RA, Yapca OE. Vaginal Misoprostol Compared With Buccal Misoprostol for Termination of Second-Trimester Pregnancy: A Randomized Controlled Trial. Obstet Gynecol. 2015 Sep;126(3):593-598. doi: 10.1097/AOG.0000000000000946. PMID 26181087