Clinical trial · Observational
Observation of Microvessels and Invasion in Early Colorectal Lesions by NBI
Observation of Microvessels and Invasion in Early Colorectal Lesions by Narrow Band Imaging:Combination With Microvessel Count and MMP-7 Expression
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Combined with magnifying endoscopy,narrow-band imaging (NBI) contrasts microvascular architecture on lesion surface.The histology of early colorectal lesions could be predicted under NBI view.However,its capability for estimating invasion depth remains to be verified.The study is based on the hypothesis:NBI can predict histology and invasion depth,combined with the verification of microvessel count and MMP-7 expression.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- NBI prediction for lesion histology and invasion
- timeFrame
- in two weeks after lesion treatment
- description
- We will receive the histologic findings in two weeks after lesion treatment.Then we can compare NBI prediction with the final histologic type.
Secondary outcomes (1)
- measure
- immunohistochemical outcome of microvessel count and MMP-7
- timeFrame
- in three days after immunohistochemistry
- description
- We will receive the immunohistochemical outcome in three days after immunohistochemistry.Then we can compare NBI prediction with immunohistochemical outcome
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * patients of early colorectal lesions with capillary pattern(CP) type II\&III,initially detected by white-light view and then examined by NBI with magnifying endoscopy. Exclusion Criteria: * lesions with CP type I; * CP type III lesions with an obvious appearance of advanced cancer; * lesions that had underwent biopsy; * patients with inflammatory bowel disease(IBD) or familial adenomatous polyposis(FAP) * patients with previous colorectal surgery; * having conditions associated with cardiac,hepatic,renal,and coagulopathy diseases.
References
Publications (0)
Data not yet available