Clinical trial · Observational
Optimization of MRI for Radiation Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, appropriate patients undergo MRI imaging with immobilization and sequences optimized for diagnostic radiology purposes. Using a mutual information algorithm, these images are then registered to a treatment planning CT obtained with custom immobilization to minimize intra-and inter-treatment motion and positional variation. This image registration process is time-consuming and introduces additional layers of geometric uncertainty into what should be a highly precise treatment planning process. However, it is necessary, since radiation dose calculations cannot be performed on MRI data due to the lack of crucial density information. The investigator envisions CT-less treatment planning, using only MRI, due to superior imaging characteristics, fully integrated into the radiation oncology clinic. This study will begin this process.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Brain | — | UNRESOLVED | — |
| Cancer Head &Neck | — | UNRESOLVED | — |
| Cancer Liver | — | UNRESOLVED | — |
| Cancer Pelvis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI Group | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- MRI group
- description
- Patient receives one research MRI prior to radiation treatment.
- interventionNames
- Procedure: MRI Group
Primary outcomes (1)
- measure
- Percentage of participants with MRI images suitable for analyses
- timeFrame
- Day One
- description
- Patients will be off protocol immediately after the single MRI scan. Comparative treatment planning will occur off-line and will not be used for patient care.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients ≥18 years of age * A working diagnosis of malignancy in the liver, brain, H\&N, or pelvis * A plan to treat with radiotherapy Exclusion Criteria: * Patients with contraindications to having a contrast enhanced MRI scan. These contraindications will be assessed at the time of enrollment using the guidelines set up and in clinical use by the Radiology Department.
References
Publications (0)
Data not yet available