Clinical trial · Observational
Retinal Oxygen Function After Radiation Therapy
Changes in Regional Retinal Oxygen Extraction and Function After Radiation Therapy
NCT02043470CI-TRIAL-00040258completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators propose using retinal oximetry to assess for abnormalities in regional retinal oxygen consumption in previously- irradiated patients, and relate these abnormalities to changes in regional retinal function (i.e. visual field abnormalities). Since different regions of retina receive different radiation doses, the investigators will assess for a dose response as well.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| A History of Radiation Therapy for a Tumor in the Vicinity of the Retina(s) | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Abnormalities in regional retinal oxygen extraction after incidental irradiation of the retina.
- timeFrame
- 2 months
- description
- To identify abnormalities in regional retinal oxygen extraction in patients who have had previous incidental irradiation of the retina.
- measure
- Prevalence of vision loss in patients with previous incidental irradiation of the retina
- timeFrame
- 2 months
- description
- To determine the prevalence of regional retinal dysfunction (i.e. vision loss) in patients with previous incidental irradiation of the retina.
Secondary outcomes (3)
- measure
- Changes in retinal oxygen extraction compared to radiation dose
- timeFrame
- 2 months
- description
- To correlate changes in retinal oxygen extraction to radiation dose.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: 1. ≥ 18 years of age at the time of radiation therapy (no upper age limit) 2. History of radiation therapy delivered at UNC-CH or Rex Hospital to the vicinity of the retina(s) ≥ 2 months prior to enrollment 3. Estimated average dose to at least one quadrant of one retina ≥ 30 Gy Exclusion Criteria: 1. History of diabetes, retinal vascular occlusions, glaucoma, retinitis pigmentosa, occipital stroke or any other ophthalmologic or systemic problem that may confound visual field results. 2. Residual tumor within the visual pathway: retina, optic nerves, optic chiasm, optic radiations and brain.
References
Publications (0)
Data not yet available
No reference posted for this study.