Clinical trial · Interventional
Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors. The nature of cardiovascular risk and the interaction between treatment affects and cardiovascular risk factors is unknown. We propose to study vascular inflammatory markers as well as measure of blood vessel stiffness (both of which are predictive of early heart disease) in 100 pediatric cancer survivors and 100 control children. Characterization of vascular inflammation and stiffness in long-term survivors will allow for the development of future interventions to decrease inflammation through both pharmacologic and lifestyle modifications.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Survivor | — | UNRESOLVED | — |
| Pediatric Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood specimen | Procedure | — | UNRESOLVED |
| Echocardiography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Intervention procedures
- description
- All the procedures will be completed for every subject
- interventionNames
- Procedure: Blood specimen
- Procedure: Echocardiography
Primary outcomes (1)
- measure
- Vascular Inflammation
- timeFrame
- single time point at initial visit
- description
- All study procedures to assess vascular inflammation will be assessed through specimen sample collection and through procedures such as (echocardiograph)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * 6-30 years of age * 2 years from the completion of therapy for cancer * free of active disease Exclusion Criteria: * \<6 or \> 30 years of age * current cancer treatment or inside of 2 years post treatment * Active disease/infection
References
Publications (0)
Data not yet available