Clinical trial · Observational
Biomarker Analysis in Metastatic Colorectal Cancer Treated With Cetuximab
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prometheus's Onco dX assay platform provides technological breakthrough for immunoassay by obtaining a level of sensitivity down to single tumor cells without compromising specificity. This allows assessment of multiple TKI treatment targets, their activation status, as well as down stream signaling proteins using very tiny amount of tissue that can be obtained by FNA or CTCs. We planned this study to explore biomarkers predictive of clinical response to cetuximab-based treatment in metastatic colorectal cancer using the Prometheus Platform. We will also elucidate signal transduction pathway attributable to cetuximab resistance, monitor changes in the RTK activation status during cetuximab treatment using circulating tumor cells and analyze correlation between the quantity of circulating tumor cells and treatment response to cetuximab.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- To explore biomarkers predictive of clinical response to cetuximab-based treatment in metastatic colorectal cancer using the Prometheus Platform
- timeFrame
- at Screening (Day - 21 ~ 0 ), at 4 weeks and average 6months(end of treatment)
- description
- A. To analyze expression and activation status of receptor tyrosine kinases in signal transduction pathways in FNA samples and circulating tumor cells B. To identify negative predictive markers to cetuximab
Secondary outcomes (3)
- measure
- 1. RTK activation status during cetuximab treatment using circulating tumor cells
- timeFrame
- at Screening (Day - 21 ~ 0 ), at 4 weeks and average 6months(end of treatment)
- measure
- 2. signal transduction pathway attributable to cetuximab resistance
- timeFrame
- at Screening (Day - 21 ~ 0 ), at 4 weeks and EOT (end of treatment)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with histologically confirmed metastatic colorectal cancer * Cetuximab-based chemotherapy (monotherapy, combination therapy with cytotoxic chemotherapy such as FOLFOX, XELOX, irinotecan, FOLFIRI, XELIRI, first-line, second-line or third-line are all eligible) * Age \> 18 years. * ECOG Performance Status of 0-2 * Adequate bone marrow, liver and renal function * Signed and dated informed consent before the start of specific protocol procedures. * FNA will be performed in patients with feasible biopsy site; ascites or pleural fluid will be collected in metastatic CRC patients with ascites or pleural effusion Exclusion Criteria: * Active clinically serious infections (\> grade 2 CTCAE version 3.0) * Patients with evidence or history of bleeding diathesis * Radiotherapy during study or within 4 weeks of start of study drug. * Prior exposure to the study drug. * Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results
References
Publications (0)
Data not yet available