Clinical trial · Interventional
Vaginal Administration of Metformin in PCOS Patients.
Impact of Vaginal Administration of Metformin in Women With PCOS.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Polycystic ovary syndrome is a common cause of irregular periods, poor ovulation and delay in achieving pregnancy. Certain drugs may help improve ovarian activity in such women as metformin. Oral administration of metformin is accompanied by undesirable side effects. The vagina proved to be a good alternative to the oral route for other drugs. Using metformin through the vagina and avoidance of such side effects, while maintaining its effectiveness, would help women to better tolerate this drug.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| PCOS | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Metformin | Drug | Metformin | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Oral metformin
- description
- Metformin 850 mg tablets taken by mouth every 12 hours for 6 months
- interventionNames
- Drug: Metformin
- type
- ACTIVE_COMPARATOR
- label
- Vaginal metformin
- description
- Metformin 850 mg tablets taken vaginally every 12 hours for 6 months
- interventionNames
- Drug: Metformin
Primary outcomes (1)
- measure
- Ovulation rates
- timeFrame
- 6 months
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * women with PCOS according to the Rotterdam criteria * age 20-35 years * not to have received any induction of ovulation in the preceding 3 months before enrollment Exclusion Criteria: * contraindications to metformin * prior surgical management of PCOS
References
Publications (0)
Data not yet available