Clinical trial · Observational
Study to Evaluate the Natural History of Head and Neck Cancer Precursors in Taiwan
Natural History Of Oral Cancer Precursor Lesions: A Prospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: \- Cancer of the mouth and throat is one of the most common cancers in Taiwan. This cancer develops over several years, beginning as white or red patches in the mouth or throat that become growths. It can also cause a condition that leads to rigidity of the cheeks. The growths can be identified when a doctor looks into a person s mouth. It is currently not clear why some people with abnormal growths progress to cancer while others do not. Researchers want to better understand why some patients with early abnormal growths get late abnormal growths. They also want to understand why some people get abnormal growths again, even after they receive treatment. Objectives: \- To understand why some people with precancerous lesions in their mouth develop cancer while others do not. Eligibility: \- Adults 21 years and older, some with abnormal growths in the mouth, some without any, and some with head and neck cancer. Design: * Participants will visit a hospital in Taiwan 2 times. * At the first visit, participants will answer questions about their health, lifestyle, and family medical history. A doctor will examine the participant s mouth and take a small piece of any growth they see. They will do this with a brush. They will also photograph the participant s mouth. Participants will also give blood and saliva samples, plus a small sample of a mouth rinse. * Participants who are diagnosed with a late abnormal growth that is not cancer will return for a second visit. They will answer the same questions and undergo the same procedures as at the first study.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Cancer
- description
- Participants diagnosed with incident oral cancer
- label
- Control
- description
- Participants without oral lesions or cancers matched to oral cancer/precursor participants on age, gender, smoking/betel nut habits
- label
- Precursor
- description
- Participants clinically diagnosed with oral lesions
Primary outcomes (1)
- measure
- Progression to dysplasia/cancer in participants with oral precursors.
- timeFrame
- Follow-up visits every 6 months for 5 years
- description
- Histologically confirmed progression to dysplasia/cancer in participants with oral precursors.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 100 Years
Show eligibility criteria text
* INCLUSION CRITERIA We plan to recruit all patients (controls, precursors, and invasive cancers) at the aforementioned two hospitals. Doctors at these hospitals conduct routine visual and tactile examination as part of Taiwan s national oral cancer screening program. For this screening program, all individuals aged 21 years or older who chew betel-quid or smoke are screened through visual inspection for the presence of precursor lesions or cancer. EXCLUSION CRITERIA Participants younger than 21 years and individuals with a history of head and neck cancer will be excluded from the study.
References
Publications (0)
Data not yet available