Sequential Paclitaxel Chemotherapy and Radiotherapy as 1st Line Treatment for Elderly Esophageal Squamous Cell Cancer

Inclusion Criteria:

1. Having signed informed consent Age more than 69 years old
2. Histologically confirmed esophageal squamous carcinoma,metastatic disease with primary tumor,no prior palliative chemotherapy;
3. No prior radiotherapy except radiotherapy at non-target lesion of the study more than 3 months
4. Sex is not limited
5. Measurable disease according to the RECIST criteria(diameter of the lesion should be more than 10mm by spiral CT or MRI, more than 20mm by common CT, the date of image should be less than 15 days before enrollment)
6. Karnofsky performance status ≥80
7. Life expectancy of ≥ 3 month
8. WBC \> 3,000/mm3, absolute neutrophil count ≥2000/mm3, platelet \> 100,000/mm3, Hb \> 9g/dl(within 14 days before enrollment),ALT and AST \< 1.5 times ULN (≤5 times ULN in patients with liver metastases),Bilirubin level \< 1.0 times ULN,Serum AKP \< 2.5 times ULN,Serum creatinine \< 1.0 times ULN
9. No sever complication, such as active gastrointestinal bleeding, perforation, jaundice, obstruction, non-cancerous fever \> 38℃；
10. Normal ECG and heart function
11. Fertile patients must use effective contraception Good compliance

Exclusion Criteria:

1. Previous treatment of palliative chemotherapy
2. Known hypersensitivity to Paclitaxel,Cisplatin
3. Only with Brain or bone metastasis
4. No measurable lesions, eg. pleural fluid and ascites
5. Suffer from severe heart disease or disease with other important organs Chronic diarrhea or renal dysfunction
6. Other previous malignancy within 5 year, except non-melanoma skin cancer
7. Mentally abnormal or disable cognition,including CNS metastasis