Clinical trial · Interventional
Robust Evaluation to Measure Improvements in Nonadherence From Low-cost Devices
Assessing the Impact of Low-Touch Devices on Medication Adherence
NCT02015806CI-TRIAL-00020487REMINDcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to determine whether adherence to oral maintenance medications differs for patients randomized to receive a RxTimerCap, a Take-N-Slide, a standard pillbox, or none of these devices, with the hypothesis that low-touch devices improve adherence over control and that the increase in adherence is agnostic across devices.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cardiovascular Disease | — | UNRESOLVED | — |
| Depression | — | UNRESOLVED | — |
| Diabetes | — | UNRESOLVED | — |
| Epilepsy | — | UNRESOLVED | — |
| Mental Health Disorder | — | UNRESOLVED | — |
| Parkinson's Disease | — | UNRESOLVED | — |
| Prostatic Hypertrophy, Benign | Benign Prostatic Hyperplasia | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pillbox | Behavioral | — | UNRESOLVED |
| RxTimerCap | Behavioral | — | UNRESOLVED |
| Take-N-Slide | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (14)
- type
- EXPERIMENTAL
- label
- All meds but depression, 1x daily use, RxTimerCap
- description
- Individuals who are taking 1-3 cardiovascular or other non-depression chronic disease medications and who are suboptimally adherent to these therapies, whose medications are all intended for once daily use, and who are randomized to receive a RxTimerCap.
- interventionNames
- Behavioral: RxTimerCap
- type
- EXPERIMENTAL
- label
- All meds but depression, 1x daily use, Take-N-Slide
- description
- Individuals who are taking 1-3 cardiovascular or other non-depression chronic disease medications and who are suboptimally adherent to these therapies, whose medications are all intended for once daily use, and who are randomized to receive a Take-N-Slide.
- interventionNames
- Behavioral: Take-N-Slide
- type
- EXPERIMENTAL
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 64 Years
Show eligibility criteria text
Inclusion Criteria: * Have 1 to 3 oral maintenance medications for chronic disease in the 12-month period prior to study eligibility evaluation * Cardiovascular disease (defined as hypertension, hyperlipidemia, coronary artery disease, congestive heart failure, or diabetes); OR * Another non-depression chronic condition (defined as breast cancer, benign prostatic hypertrophy, schizophrenia, bipolar disorder, anxiety, arrythmia; Parkinson's disease, seizure, and epilepsy); OR * Depression * Be suboptimally adherent to their qualifying medications, defined as a Medication Possession Ratio between 30% and 80% during the 12 months preceding identification of study eligibility * Eligible for pharmacy benefits during the 12 months prior to being identified as being eligible for the study and expected to be eligible for pharmacy benefits through the end of the evaluation period. Exclusion Criteria: * Enrolled in Ready Fill at Mail (a pharmacy benefit program whereby members elect to have medications shipped automatically to them at the time of refill due date or prescription renewal).
References
Publications (2)
- DERIVEDAl-Aqeel S, Gershuni O, Al-Sabhan J, Hiligsmann M. Strategies for improving adherence to antiepileptic drug treatment in people with epilepsy. Cochrane Database Syst Rev. 2020 Oct 22;10(10):CD008312. doi: 10.1002/14651858.CD008312.pub4. PMID 33089492
- DERIVEDChoudhry NK, Krumme AA, Ercole PM, Girdish C, Tong AY, Khan NF, Brennan TA, Matlin OS, Shrank WH, Franklin JM. Effect of Reminder Devices on Medication Adherence: The REMIND Randomized Clinical Trial. JAMA Intern Med. 2017 May 1;177(5):624-631. doi: 10.1001/jamainternmed.2016.9627. PMID 28241271