Clinical trial · Interventional
Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer
NCT02012244CI-TRIAL-00020505completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| fentanyl-based analgesia | Drug | — | UNRESOLVED |
| local anesthetic wound infiltration-based anlagesia | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- fentanyl-based analgesia
- description
- fentanyl intravenous patient-controlled analgesia + additional pethidine
- interventionNames
- Drug: fentanyl-based analgesia
- type
- EXPERIMENTAL
- label
- local anesthetic wound infiltration-based anlagesia
- description
- continuous wound inflitration with ropivacaine + tramadol intravenous patient-controlled analgesia + additional ketorolac or propacetamol
- interventionNames
- Drug: local anesthetic wound infiltration-based anlagesia
Primary outcomes (2)
- measure
- NK cell activity
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * ASA class I-III * 20-80 years old * elective laparoscopic colorectal surgery for cancer Exclusion Criteria: * drug allergy * significant renal or hepatic impairment * sign of infection
References
Publications (1)
- DERIVEDNunez-Rodriguez E, Zhang H, Sah D, Cata JP. Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going? Adv Biol (Weinh). 2025 Oct;9(10):e00122. doi: 10.1002/adbi.202500122. Epub 2025 Aug 7. PMID 40772525