Clinical Study of Endostar Injection Concomitant With SOX Protocols to Treat Advanced Gastric Cancer

Inclusion Criteria:

* Age: 18～70 years;
* Performance status (PS) of Eastern Cooperative Oncology Group (ECOG) was 0～1 or KPS scores were 60-100 scores;
* Patients who were diagnosed with recurrent and metastatic advanced gastric cancer by histopathology and CT;
* Patients who had more than 1 measurable nidus (common CT or MRI scanning ≥20 mm, spiral CT scanning ≥10 mm);
* Patients who had no severe dysfunction of important organs, and were normal in blood routine test, hepatorenal function, electrolytes and cardiac function, with white blood cell count≥4.0×109/L, neutrophil count≥1.5×109/L, platelet count≥100×109/L, hemoglobin≥95g/L, serum bilirubin≤1.5 folds of upper normal limit, Alanine transaminase and glutamic oxalacetic transaminase ≤2 folds of upper normal limit, and serum creatinine≤1.5mg/dl.
* Estimated survival time was above 3 months;
* Patients who were well acknowledged of this study and signed the informed consent forms.

Exclusion Criteria:

* Patients who received whole body treatment of metastatic gastric cancer previously;
* Patients who underwent surgeries within 4 weeks before this study;
* Patients who had allergic constitutions or were allergic to biological products of proteins and to any medicine used in this study;
* Female patients in gestation or lactation period, or those who were interfile but received no contraception measures;
* Patients who were with other symptoms unsuitable to this study;
* Patients who were treated by other anti-tumor methods at that time;
* Patients who had no measurable nidus;
* Patients who had one of the following conditions: uncontrolled metastatic nidus in central nervous system, dysfunction of important organs, severe cardiac diseases (including congestive heart failure, uncontrollable arrhythmia, angina pectoris needed long-term drug treatment, valvular heart diseases and myocardial infarction), hypertension, women in gestation or lactation period, protracted infectious wound as well as uncontrollable psychosis history.