Clinical trial · Interventional
Mobility and Activity Training (MAT) to Optimize Outcomes for Older Adult Abdominal Surgery Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Difficulty enrolling
Summary
Brief summary (as posted)
In this pilot study a group of older adults undergoing midline laparotomy for gastrointestinal malignancy will participate in a mobility and activity training (MAT) program. MAT is designed to advance functional mobility and physical activity and spans the pre-operative, inpatient, and post-operative period. Patients undergoing abdominal surgery will be randomized to MAT versus control usual care and evaluated at their first appointment 4 weeks preoperatively (baseline), immediately prior to surgery, on hospital discharge, and 6 weeks post operatively. We hope to prove that abdominal surgery patients undergoing MAT will show less decline and earlier recovery in functional activity, and trunk and thigh muscle strength mass. This study is uniquely innovative in that it links functional activity assessment and training and analysis of trunk morphomics (muscle mass) in exploring mechanisms of post-operative recovery. Results from this pilot will be used to determine an effect size for the recruitment of a larger cohort and to study key surgical outcomes, including surgical complications, operative symptoms, hospital length of stay, and cost of care.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Malignancy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mobility and Activity Training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Mobility and Activity Training
- description
- Pre-operative: Participants will receive weekly sessions of higher level, task-specific transfer training. All MAT participants will learn the GCS set of exercises chosen to activate core muscles and lessen decline in core strength. These sessions will be supplemented by a home-based walking and physical activity enhancement program of the participants' choosing, focusing on attaining a safe community-based rate of perceived exertion. A pedometer and home exercise log will be used to encourage compliance and advance activities. Post-operative: Participants will be screened by physical therapy for standard physical therapy with focus on early mobilization. The GCS exercises taught pre-operatively will be reinstituted. Post-discharge/home: Participants will continue the GCS program and begin to return to elements of their pre-operative home-based MAT program. The program physical therapist will call weekly to review progress.
- interventionNames
- Behavioral: Mobility and Activity Training
- type
- NO_INTERVENTION
- label
- Normal activity
- description
- Pre-operative: Participants will be given the National Institute on Aging guide to home-based exercise but no further instruction or incentive for walking or physical activity enhancement. Post-operative: Participants will be screened by in-hospital physical therapy for standard physical therapy with focus on early mobilization. Those who do not receive physical therapy will not be given any additional training, as is standard for reimbursed hospital services. Post-discharge: Program nurse will call weekly to provide health education but no instruction or incentives for mobility or physical activity enhancement.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Elective laparotomy for GI malignancy (colon resection, pancreatic resection, hepatectomy, resection of the bile ducts) * Complete surgical resection (surgery on presumed cancer considered resectable by the attending surgeon. Exclusion Criteria: * Presumed benign disease as the indication for surgical resection. * Received neo-adjuvant chemotherapy or radiation. * Having preoperative severe hypo-albuminemia (albumin less than 3.0 g/dL). * Having a previous ventral hernia repair or abdominal wall reconstruction. * Morbid obesity (BMI\>40) * Participating in intensive (30 min per day) aerobic exercise program three times per week. * Ongoing physical therapy in a relevant area (e.g. leg strengthening, balance and gait training) * Myocardial infarction \< 1 month * Active symptoms of heart failure (NYHA grade II or higher) * Atrial fibrillation with poor rate control (particularly during exercise) or high grade AV block * Symptomatic obstructive valvular disease (primarily during exercise) * Significant COPD * Brittle diabetes (type I diabetes or multiple hypoglycemic episodes requiring assistance) * Significant anemia (Hgb\<7.0) * Substantial dementia (Folstein Mini Mental State Examination \<24 our of 30) * Blood tests suggesting severe renal impairment (Cr\>3.0) * Alcohol intake \>3oz/day * Hemiplegia or lower limb amputation * Acute medical conditions, such as acute flare-up of joint condition or infection * Significant orthopedic or musculoskeletal condition that limits weight bearing activities * Chronic pain syndrome affecting truncal areas (e.g. fibromyalgia) * Unable to safely stand and walk, either with or without an assistive device
References
Publications (0)
Data not yet available