Clinical trial · Interventional
Acute Exercise Cardioprotection From Doxorubicin
The Effects of Exercise Before Doxorubicin Chemotherapy on Cardiac Function
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury. This study will investigate whether this finding translates to human breast cancer patients. Participants scheduled to receive chemotherapy for breast cancer will be randomized to exercise or no exercise 24 hours prior to every chemotherapy treatment. The effect on cardiac function will be compared between groups noninvasively by echocardiography and electrocardiography and a venous blood draw at baseline before chemotherapy, after the first treatment and at the end of chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| exercise | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise
- description
- an acute bout of exercise performed ≤24 hours prior to each cycle of anthracyclines and no exercise for 48 hours post
- interventionNames
- Other: exercise
- type
- NO_INTERVENTION
- label
- No exercise
- description
- no exercise for 72 hours prior or 48 hours post each cycle of anthracyclines
Primary outcomes (1)
- measure
- Global Longitudinal Strain
- timeFrame
- 24-48 hours after first doxorubicin and 7-14 days after completion of last doxorubicin cycle
- description
- Assessed with 2D speckle tracking echocardiography
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * newly diagnosed with stage I-IIIA breast cancer * scheduled to receive neoadjuvant or adjuvant doxorubicin chemotherapy in cycles of 2-3 weeks long * receive their oncologist's approval to exercise * be able to complete first time point of data collection prior to first chemotherapy cycle * be able to understand and provide written informed consent in English Exclusion Criteria: * concurrent participation in a structured exercise program or study * have orthopedic limitations to exercise * pre-existing cardiovascular disease * uncontrolled hypertension (blood pressure ≥ 140/90 mmHg) * uncontrolled diabetes * respiratory disease * current smoking status
References
Publications (0)
Data not yet available