Clinical trial · Observational
Metabolic Tumor Volumes in Radiation Treatment of Primary Brain Tumors
Evaluation of Metabolic Tumor Volumes in Radiation of Primary Brain Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
* Metabolic Tumor Volume (MTV), identified by Magnetic Resonance Spectroscopic Imaging (MRSI) is different from the Clinical Target Volume (CTV) used for radiation dose delivery in the treatment of brain tumors. * If MTV \> CTV, the investigators hypothesize that the difference in volumes (cc) is related to worse clinical outcome. Furthermore, in case of local recurrence, the lesion is located in the MTV area that is outside of the CTV. * Alternatively, if CTV \> MTV, then the difference in volumes is related to higher treatment toxicity.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
| Glioblastoma Multiforme | Glioblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Difference between Metabolic Tumor Volumes and Clinical Tumor Volumes in Patients with Brain Tumors
- timeFrame
- 2 years
- description
- To evaluate the extent to which tumor volumes, determined by spectroscopic imaging (MTV) differ from the traditionally prescribed clinical treatment volumes (CTV) for radiation therapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients must have histologically confirmed primary brain tumor. * Patients may be enrolled prior to surgery, after surgical resection or with unresectable tumors. * Patients must be 18 years or older. * Patients who do not have metal in the body (e.g. pacemakers, implants) that would preclude them from undergoing MRI/MRS exam * Patients who do not suffer from claustrophobia (fear of enclosed spaces) * Karnofsky performance status ≥ 60. * Patients whose size would allow them to fit into the bore of the MRI instrument. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients younger than 18 years. * Inability to undergo MRI/MRS exam because of metal in the head or body, such as implants, pacemaker, or biostimulation device. Claustrophobia (fear of enclosed spaces). * Karnofsky performance status \< 60. * Patients too large (\> 300 lbs.) to fit into the bore of the MRI instrument. * Inability to understand the informed consent document.
References
Publications (0)
Data not yet available