Window of Opportunity Study of VS-6063 (Defactinib) in Surgical Resectable Malignant Pleural Mesothelioma Participants

Inclusion Criteria:

* Histologically confirmed malignant pleural mesothelioma that is not metastatic or unresectable
* Eligible to undergo excisional surgery such as pleurectomy/decortication (P/DC) or any other mesothelioma surgery.
* Localized disease. The malignancy is confined to one affected hemithorax. Mediastinal N2 lymph nodes via cervical mediastinoscopy or EBUS (endobronchial ultrasound) must be negative in order to be eligible
* Grossly normal pulmonary, cardiac function, renal, hepatic hematologic and performance functions
* Male or non-pregnant female
* Age ≥ 18 years of age
* Tissue is required prior to enrollment. If patient was diagnosed outside and tumor tissue is not available, a pleural biopsy for frozen tissue collection is required.

Exclusion Criteria:

* Participants who have had chemotherapy or radiotherapy any time prior to entering the study or at any prior time for mesothelioma. Patients receiving chemotherapy type drugs for benign conditions can participate in this trial
* History of upper gastrointestinal bleeding, ulceration, or perforation within 12 months prior to the first dose of study drug
* Known history of Gilbert's Syndrome or any current hyperbilirubinemia of any cause
* Known history of stroke or cerebrovascular accident within 6 months prior to the first dose of study drug
* Subjects with known infection with human immunodeficiency virus (HIV) or Acquired Immune Deficiency Syndrome (AIDS)
* Subjects with confirmed Hepatitis A, B or C
* Subjects being actively treated for a secondary malignancy or any malignancy within the last 3 years, with the exception of non-melanomatous skin cancer or localized, definitively treated cervical cancer. Men under observation for local prostate cancer are also eligible if they have had stable disease for at least 1 year.
* Uncontrolled or severe cardiovascular disease, including myocardial infarct or unstable angina within 6 months prior to study treatment, New York Heart Association (NYHA) Class II or greater congestive heart failure, serious arrhythmias requiring medication for treatment, clinically significant pericardial disease, or cardiac amyloidosis
* Known history of malignant hypertension
* Uncontrolled intercurrent illness including symptomatic congestive heart failure, cardiac arrhythmia, or psychiatric illness/social situations which in the opinion of the study investigators would be associated with undue risk of participation in the study
* Use of an investigational drug within 28 days or 5 half-lives prior to first dose.
* Pregnant or breastfeeding