Clinical trial · Interventional
Radiofrequency-assisted Hepatectomy on the Outcomes of HCC Patients With Cirrhosis
The Influence of Radiofrequency-assisted Hepatectomy on the Perioperative Outcomes and the Long-term Prognosis of HCC With Cirrhosis：A Prospective Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Surgical resection is the most effective treatment of primary and secondary liver tumors. Technical innovations have mainly focused on minimizing bleeding during transection of the hepatic parenchyma because excessive hemorrhage and the need for blood transfusion are associated with increased postoperative morbidity and mortality. Recently,radiofrequency-assisted（RFA）hepatectomy has developed rapidly and gained widespread acceptance for the treatment of hepatocellular carcinomas（HCC），but its influence on the prognosis of HCC patients，especially for those with cirrhosis，is still controversial. Therefore, we design this prospective clinical trial to explore the effect of RFA hepatectomy versus the conventional hepatectomy on the outcomes of perioperative period and prognosis of HCC patients with cirrhosis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cirrhosis | — | UNRESOLVED | — |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Hepatectomy | Procedure | — | UNRESOLVED |
| Radiofrequency-assisted Hepatectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- radiofrequency-assisted resection group（RF-R)
- description
- Radiofrequency-assisted resection: separating the tumor from liver by using the probe of radiofrequency to block the arterial and vessels before parenchymal transection.
- interventionNames
- Procedure: Radiofrequency-assisted Hepatectomy
- type
- ACTIVE_COMPARATOR
- label
- conventional liver resection group（CLR-R）
- description
- Conventional liver resection group: hepatectomy only without RF assisted during parenchymal transection.Separating and dissecting the tumor with the routine clamp-crushing technical.
- interventionNames
- Procedure: Conventional Hepatectomy
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Aged from 18 to 65 years , no gender restriction. * Clinical diagnosis of resectable HCC. * Preoperative liver function test showed Child-Pugh Class A or B. * Indocyanine green retention at 15 minutes (ICG-15) of \<30%. * Acceptable clotting profile :platelet count \> 50 x 109/L and a prolonged prothrombin time of \< 5 seconds. * Enough relative residual liver volume (%RLV) ≥ 40%. * No tumor invasion in primary branch of portal vein, hepatic vein, or inferior vena cava. * No other anti-tumor therapy received before the treatment. * No metastasis in lymphnode or other organs. * Written consent inform assigned. Exclusion Criteria: * Pregnancy. * Intraoperative findings of tumor rupture，extrahepatic tumor or lymphnode metastasis. * Tumor invasion in primary branch of portal vein, hepatic vein, or inferior vena cava.
References
Publications (0)
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