Clinical trial · Observational
Correlation Research of Thioredoxin Reductase in Lung Cancer
Correlation Study of Blood and Tissue Thioredoxin Reductase Activity in Early Stage On-small Cell Lung Cancers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In pre-clinical study the investigators found that the thioredoxin reductase activity of serum harbours huge difference between cancer patients and non-cancer patients, the enzyme activity elevated remarkably among cancer patients, so the investigators hypothesis that this is due to tumor cells loading of the patients, the enzyme activity may harbours huge difference between carcinoma tissues and para-carcinoma tissues in early staged non-small cell lung cancers, and after surgery, the enzyme activity may fall down to a normal level because of removing of tumor.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Neoplasm of Lung | Benign Lung Neoplasm | ALIAS | 0.90 |
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- early staged non-small cell lung cancers
- description
- patients who diagnosed as early staged non-small cell lung cancer after surgery
- label
- lung benign mass patients
- description
- patients who diagnosed as lung benign mass after surgery
Primary outcomes (1)
- measure
- measure the thioredoxin reductase activity in blood, tumor and pericarcinomatous tissue
- timeFrame
- blood should be taken in 2 days before surgery, tumor and pericarcinomatous tissues should be stored and tested in one month
- description
- 3-4 ml blood should be taken and centrifuged in 30 mins, then the serum should be stored at -20 degree, then serum thioredoxin reductase activity should be measured in one month. Tumor and pericarcinomatous tissues should be stored at -180 degree and enzyme activity should be measured within one month
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Pathologically proven staged(Ⅰ\~ⅢA) non-small cell lung cancer or CT scan shows resectable lung mass * Receive surgery in Thoracic Oncology department Hunan Tumor Hospital without contraindication of surgery * Malignant tumor treatment naive（except for surgery for cervical cancer and cutaneous squamous cell carcinoma 5 years before） * Signed informed consent about providing blood and tissue for study Exclusion Criteria: * Patients have received antitumor treatment * Patients with contraindication of surgery or patients who need adjuvant chemotherapy with contraindication of chemotherapy * Pregnant or breast feeding women
References
Publications (0)
Data not yet available