Clinical trial · Interventional
Effect of Zinc on Barrett's Metaplasia
NCT01984580CI-TRIAL-00012633unknownPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Using orally administered zinc to patients already diagnosed with the pre-cancerous condition, Barrett's Esophagus, this study is asking two questions: 1. can this zinc administration cause molecular-level changes in the Barrett's tissue? 2. are the changes measured indicative of chemopreventive action by zinc regarding cancer progression?
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Barrett's Metaplasia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| zinc gluconate | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Zinc
- interventionNames
- Drug: zinc gluconate
- type
- PLACEBO_COMPARATOR
- label
- sodium
Primary outcomes (1)
- measure
- Changes in zinc-regulated cellular proteins within Barrett's tissue
- timeFrame
- in biopsy tissue after 14 days of Zn exposure
Secondary outcomes (1)
- measure
- Changes in cellular microRNA profile; changes in protein cancer biomarkers
- timeFrame
- in biopsy tissue after 14 days of Zn exposure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria:ages 18-80; prior diagnosis of Barrett's esophagus - Exclusion Criteria:unable to provide written, informed consent; prior history of Barrett's dysplasia or esophageal adenocarcinoma; drug exclusions: hormone replacement therapy, cholestyramine, amiloride diuretics, oral quinolone antibiotics, glucocorticoids, corticosteroids, anticoagulants (other than aspirin) \-
References
Publications (0)
Data not yet available
No reference posted for this study.