Clinical trial · Observational
Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Lack of funding
Summary
Brief summary (as posted)
Lung cancer, largely the result of cigarette smoking, is the leading cause of cancer death in the United States, killing over 160,000 people in 2010, more than breast, colorectal, and prostate cancer combined. Since only 10% of heavy smokers develop lung cancer and 20% of lung cancers develop in nonsmokers, it is thought that genetic predisposition plays an important role. This study proposes to examine the genetic correlation between nasal and bronchial epithelium and to identify a patient's risk for lung cancer earlier.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Obstructive Pulmonary Disease | — | UNRESOLVED | — |
| COPD | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Group 1 | Genetic | — | UNRESOLVED |
| Group 2 | Genetic | — | UNRESOLVED |
| Group 3 | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Group 1
- description
- Non-smokers (n=20)
- interventionNames
- Genetic: Group 1
- label
- Group 2
- description
- Non-smokers (n=20), Smokers (n=20) and Individuals with lung cancer (n=20)
- interventionNames
- Genetic: Group 2
- label
- Group 3
- description
- Subjects with abnormalities (nodules) detected on CT (n=20)
- interventionNames
- Genetic: Group 3
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: HEALTHY VOLUNTEER RESEARCH SUBJECTS * All study subjects should be able to provide informed consent * Males or females ages 18 years and older * Must provide HIV informed consent VOLUNTEER RESEARCH SUBJECTS WITH LUNG DISEASE * Must provide informed consent * Males and females age 18 years and older * Lung disease proven by at least one of the following: symptoms consistent with pulmonary disease; (2) chest X-rays consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; and/or (6) diseases of organs with known association with lung disease * Must provide HIV informed consent Exclusion Criteria: HEALTHY VOLUNTEER RESEARCH SUBJECTS * Individuals not deemed in good overall health by the investigator will not be accepted into the study. * Habitual use of drugs and/or alcohol within the past six months (Acceptable: - Marijuana one time in three months; average of two alcoholic beverages per day; drug and/or alcohol abuse is defined as per the DSM-IV Substance Abuse Criteria). * Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study. * Individuals with allergies to atropine or any local anesthetic will not be accepted into the study. * Individuals with allergies to pilocarpine, isoproterenol, terbutaline, atropine or aminophylline will not be accepted into the study. * Females who are pregnant or nursing will not be accepted into the study VOLUNTEER RESEARCH SUBJECTS WITH LUNG DISEASE * Any history of allergies to xylocaine, lidocaine, versed, valium, atropine, pilocarpine, isoproterenol, terbutaline, aminophylline, or any local anesthetic will not be included in the study. * Habitual use of drugs and/or alcohol within the past six months (Acceptable: Marijuana one time in three months; average of two alcoholic beverages per day; drug and/or alcohol abuse is defined as per the DSM-IV Substance Abuse Criteria) * Females who are pregnant or nursing
References
Publications (0)
Data not yet available