Clinical trial · Interventional
SPECT/CT in Measuring Lung Function in Patients With Cancer Undergoing Radiation Therapy
Pulmonary Functional Imaging for Radiation Treatment Planning
NCT01982123CI-TRIAL-00036125completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot clinical trial studies single photon emission computed tomography (SPECT)/computed tomography (CT) in measuring lung function in patients with cancer undergoing radiation therapy. Diagnostic procedures that measure lung function may help doctors find healthy lung tissue and allow them to plan better treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Carcinoma | Lung Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Malignant Neoplasm | Malignant Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Single Photon Emission Computed Tomography | Procedure | — | UNRESOLVED |
| SPECT/CT | Diagnostic Test | — | UNRESOLVED |
| Technetium Tc-99m Albumin Aggregated | Radiation | — | UNRESOLVED |
| Technetium Tc-99m DTPA | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- SPECT/CT Mid-& Post-RT
- description
- Investigational 99mTc-MAA and 99mTc-DTPA SPECT/CT mid-radiation therapy (up to 1 week post-treatment), and at 3-6 months post-treatment.
- interventionNames
- Diagnostic Test: SPECT/CT
- Procedure: Single Photon Emission Computed Tomography
- Radiation: Technetium Tc-99m Albumin Aggregated
- Drug: Technetium Tc-99m DTPA
Primary outcomes (1)
- measure
- Spatial Stability of Lung Perfusion and Ventilation Over Time, as Assessed Using 99mTc-MAA SPECT/CT
- timeFrame
- Baseline to up to 3 months post-treatment
- description
- Perfusion and ventilation on SPECT/CT pre-radiation, mid-radiation, and post-radiation were compared to assess stability over time. Coefficient of determination (R²) was generated based on voxel-based comparisons between scans (R²=1 means perfect reproducibility in perfusion and ventilation between scans), based on regions outside the radiation field.
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Cancer patients receiving radiation treatment to the thorax to at least 45 Gy; patient must have pathologic confirmation of diagnosis, or have an enlarging lung mass on at least two scans spaced 3 months apart, and FDG avidity on PET scan * Patients must be planned for at least 45 Gy of thoracic radiation * Patients are not required to have measurable disease; post-operative patients (patients who have had surgical resection of the lung) are eligible * Patients must have pulmonary function as defined below: * Abnormal pulmonary function test within 3 months of study entry * Prior radiation to the lungs * Prior surgical resection of lung tissue (i.e. wedge resection, lobectomy, or pneumonectomy) * Clinical diagnosis of chronic obstructive pulmonary disease (COPD) or emphysema * Ongoing oxygen use * There are no limits on prior therapy; patients are allowed to have prior chemotherapy, radiation therapy, and surgery; patients are allowed to have concurrent chemotherapy with radiation treatment; patients are allowed to have chemotherapy after radiation treatment; patients are not allowed to have planned lung resection after radiation * Ability to understand and the willingness to sign a written informed consent document * Patients will typically be enrolled on this trial prior to beginning the radiation treatment course; however, if a patient has had a SPECT/CT 99mTc-MAA and 99mTc-DTPA scan as part of routine medical care within 6 weeks prior to initiation of radiation treatment, he/she is eligible for trial enrollment up to the last day of the radiation treatment course Exclusion Criteria: * Patients must not be planned for lung resection after radiation therapy * Patients receiving \< 45 Gy radiation * Patients who received radiation to the chest within the past 6 months * Patients unable to tolerate a SPECT/CT 99mTc-MAA and 99mTc-DTPA scan * Patients who are not planning to adhere to the required follow up schedule as outlined in this protocol * Pregnant women * Women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception * Patients unable to provide informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.