Clinical trial · Interventional
General Anesthesia Combined With Epidural Anesthesia Mitigates the Surgical Stress-related Immunosuppression in Patients With Colorectal Cancer
NCT01978717CI-TRIAL-00012600completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to prove whether general anesthesia combined with epidural anesthesia could better maintain body balance of Th1/Th2 and Treg/Th17 compared with general anesthesia, so as to reduce the surgical stress-related immunosuppression, and to improve the prognosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| epidural anesthesia | Procedure | — | UNRESOLVED |
| general anesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- general anesthesia & epidural anesthesia
- description
- 26 patients received general anesthesia combined with epidural anesthesia for surgery, and patient-controlled epidural analgesia for 2 days after surgery
- interventionNames
- Procedure: epidural anesthesia
- Procedure: general anesthesia
- type
- EXPERIMENTAL
- label
- general anesthesia
- description
- 27 patients received general anesthesia for surgery, and patient-controlled intravenous analgesia for 2 days after surgery
- interventionNames
- Procedure: general anesthesia
Primary outcomes (1)
- measure
- The changes of peripheral immune cells and cytokines
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 51 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * patients with Colorectal Cancer(CRC); * subjected to the Fast-Track processing of surgery; * between 18 and 75 years old. Exclusion Criteria: * American Society of Anesthesiologists(ASA) grade \> III; * BMI \> 30; * a history of abdominal surgery, endocrine or immune system dysfunction; * recent blood transfusions, hormone or non-steroidal anti-inflammatory therapy during the past month; * previous contraindication to epidural anesthesia.
References
Publications (1)
- BACKGROUNDChen WK, Miao CH. The effect of anesthetic technique on survival in human cancers: a meta-analysis of retrospective and prospective studies. PLoS One. 2013;8(2):e56540. doi: 10.1371/journal.pone.0056540. Epub 2013 Feb 20. PMID 23437162