Clinical trial · Interventional
Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia
A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer
NCT01975064CI-TRIAL-00062688CANcompletedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Neoplasms | Breast Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Colonic Neoplasms | Colon Neoplasm | ALIAS | 0.90 |
| Rectal Neoplasms | Rectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol | Drug | — | UNRESOLVED |
| Sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Propofol
- description
- Propofol for maintenance of anesthesia
- interventionNames
- Drug: Propofol
- type
- ACTIVE_COMPARATOR
- label
- Sevoflurane
- description
- Sevoflurane for maintenance of anesthesia
- interventionNames
- Drug: Sevoflurane
Primary outcomes (1)
- measure
- Over all survival
- timeFrame
- Five years
- description
- Measured from day of surgical procedure to day of death or day of censoring
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Be informed of the nature of the study and have provided written informed consent * At least 18 years of age * Patient that is scheduled for elective radical breast- or colorectal cancer surgery in general anesthesia. Radical surgery means that the aim of the surgery is to cure (adjuvant treatment such as chemotherapy and/or radiation therapy seen as part of the curative treatment). Exclusion Criteria: * The surgery that is going to be made is an acute surgical procedure * The surgery that is going to be made is palliative surgery * Known or suspected hypersensitivity to either propofol or sevoflurane or presence of any contraindication according to the substances' valid summary of product characteristics. * Lack of suitability for participation in the trial, for any reason, as judged by the Investigator (e.g. communicative disturbances (language or intellectual)).
References
Publications (27)
- RESULTArain MR, Buggy DJ. Anaesthesia for cancer patients. Curr Opin Anaesthesiol. 2007 Jun;20(3):247-53. doi: 10.1097/ACO.0b013e32814f1c34. PMID 17479030
- RESULTBrand JM, Kirchner H, Poppe C, Schmucker P. The effects of general anesthesia on human peripheral immune cell distribution and cytokine production. Clin Immunol Immunopathol. 1997 May;83(2):190-4. doi: 10.1006/clin.1997.4351. PMID 9143381
- RESULTBraz MG, Magalhaes MR, Salvadori DM, Ferreira AL, Braz LG, Sakai E, Braz JR. Evaluation of DNA damage and lipoperoxidation of propofol in patients undergoing elective surgery. Eur J Anaesthesiol. 2009 Aug;26(8):654-60. doi: 10.1097/eja.0b013e328329b12c. PMID 19593899
- RESULTDeegan CA, Murray D, Doran P, Ecimovic P, Moriarty DC, Buggy DJ. Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitro. Br J Anaesth. 2009 Nov;103(5):685-90. doi: 10.1093/bja/aep261. Epub 2009 Sep 22. PMID 19776028
- RESULTDeegan CA, Murray D, Doran P, Moriarty DC, Sessler DI, Mascha E, Kavanagh BP, Buggy DJ. Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery. Reg Anesth Pain Med. 2010 Nov-Dec;35(6):490-5. doi: 10.1097/AAP.0b013e3181ef4d05. PMID 20975461
- RESULTGilliland HE, Armstrong MA, Carabine U, McMurray TJ. The choice of anesthetic maintenance technique influences the antiinflammatory cytokine response to abdominal surgery. Anesth Analg. 1997 Dec;85(6):1394-8. doi: 10.1097/00000539-199712000-00039. PMID 9390615
- RESULTGordon RJ. Anesthesia dogmas and shibboleths: barriers to patient safety? Anesth Analg. 2012 Mar;114(3):694-9. doi: 10.1213/ANE.0b013e3182455b86. No abstract available. PMID 22358052