Clinical trial · Interventional
Dexamethasone-induced Hiccup in Chemotherapy Patients Treated by Methylprednisolone Rotation
Antiemetic Corticosteroid Rotation From Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated With Chemotherapy: A Randomized, Single-Blind, Crossover Phase III Trial
NCT01974024CI-TRIAL-00027255completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment of DIH.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dexamethasone-induced Hiccup in Chemotherapy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| methylprednisolone | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Methylprednisolone
- description
- Dexamethasone was replaced with methylprednisolone as an antiemetic.
- interventionNames
- Drug: methylprednisolone
- type
- ACTIVE_COMPARATOR
- label
- Dexamethasone
- description
- Dexamethasone was re-administered in the cycle.
- interventionNames
- Drug: methylprednisolone
Primary outcomes (1)
- measure
- The intensities of hiccups
- timeFrame
- 2 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * all solid cancer patients on chemotherapy * age \>18 years * received dexamethasone as an antiemetic Exclusion Criteria: * brain metastases * hiccups before dexamethasone administration * uncontrolled diabetes mellitus * uncontrolled esophagitis or peptic ulcer
References
Publications (1)
- DERIVEDGo SI, Koo DH, Kim ST, Song HN, Kim RB, Jang JS, Oh SY, Lee KH, Lee SI, Kim SG, Park LC, Lee SC, Park BB, Ji JH, Yi SY, Lee YG, Yun J, Bruera E, Hwang IG, Kang JH. Antiemetic Corticosteroid Rotation from Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated with Chemotherapy: A Randomized, Single-Blind, Crossover Phase III Trial. Oncologist. 2017 Nov;22(11):1354-1361. doi: 10.1634/theoncologist.2017-0129. Epub 2017 Jul 7. PMID 28687626