A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Patients With Advanced or Refractory Solid Tumors or Lymphoma

Inclusion Criteria:

* Part 1: Histologically or cytologically confirmed solid malignancy or lymphoma that is metastatic or unresectable, and for which standard curative treatment is no longer effective
* Part 2: Histologically or cytologically confirmed gastric adenocarcinoma including gastroesophageal junctions that is metastatic, locally advanced or unresectable, and for which standard treatment is no longer effective or tolerable
* Eastern Cooperative Oncology Group performance status score 0 or 1
* Adequate bone marrow, liver, and renal function according to protocol-defined criteria within the 7 days prior to Day 1 of Cycle 1
* Laboratory values within protocol -defined parameters
* Agrees to protocol-defined use of effective contraception
* Negative urine pregnancy test (urine or serum beta human chorionic gonadotropin \[beta-HCG\]) at screening for women of child bearing potential

Exclusion Criteria:

* Has had chemotherapy, radiotherapy, immunotherapy, or treatment with an investigational anticancer agent within 3 weeks (nitrosoureas and mitomycin C within 6 weeks) before the first administration of study drug (localized radiation therapy for palliative purposes and ongoing luteinizing hormone-releasing hormone agonists and antagonists for patients with prostate cancer, bisphosphonates and denosumab are permitted
* History or current condition of uncontrolled cardiovascular disease as defined in the protocol
* Taking medications known to have a risk of causing QTc prolongation and Torsades de Pointes or known as strong CYP3A inhibitors or inducers
* Left ventricular ejection fraction less than (\<) 50 percent (%) as assessed by echocardiography (or multi-gated acquisition \[MUGA\]) performed at screening
* Uncontrolled intercurrent illness including, but not limited to, poorly controlled hypertension or diabetes, ongoing active infection, psychiatric illness, or a risk of gastrointestinal perforation

Woman who is pregnant, breast-feeding, or planning to become pregnant or is a man who plans to father a child, while the participant is enrolled in this study and is within 3 or 5 months, respectively, after the last dose of the study drug

* Not recovered from reversible, clinically significant toxicity of prior anticancer therapy
* Presence of any medical condition that requires intact wound healing capacity and is expected to endanger participant safety if wound healing capacity would be severely reduced during administration of the investigational agent
* Major surgery within 4 weeks before enrollment
* Known human immunodeficiency virus infection
* Known hepatitis B or C (except hepatocellular carcinoma)
* Active, symptomatic, or untreated brain metastasis