To Determine the Maximum Tolerated Dose (MTD) of BIBF 1120 in Patients With Solid Tumours

Inclusion Criteria:

* Patients with confirmed diagnosis of advanced, non resectable and / or metastatic solid tumours, who have failed conventional treatment, or for whom no therapy of proven efficacy exists, or who are not amenable to established forms of treatment
* Evaluable tumour deposits by one or more techniques (X-ray, CT, MRI, ultrasound)
* Age 18 years or older
* Life expectancy of at least three months
* Patients had to give written informed consent (which must be consistent with International Conference on Harmonization Good Clinical Practice (ICH-GCP) and local legislation)
* Eastern Cooperative Oncology Group (ECOG) performance score \< 2
* Full recovery from all therapy-related toxicities from previous chemo-, hormone-,immuno-, or radiotherapy

Exclusion Criteria:

* History of relevant surgical procedures during the last four weeks prior to treatment with the trial drug, or active ulcers, or injuries with incomplete wound healing
* Pregnancy or breastfeeding
* Active infectious disease
* Brain metastases requiring therapy
* Absolute neutrophil count less than 1500 / mm3
* Platelet count less than 100 000 / mm3
* Bilirubin greater than 1.5 mg / dl (\> 26 μmol / L, International System of Units (SI unit) equivalent)
* Aspartate amino transferase (AST) and / or alanine amino transferase (ALT) greater than three times the upper limit of normal (if related to liver metastases greater than five times the upper limit of normal)
* Serum creatinine greater than 1.5 mg / dl (\> 132 μmol / L, SI unit equivalent)
* Uncontrolled, severe hypertension
* Gastrointestinal disorders anticipated to interfere with the resorption of the study drug
* Serious illness or concomitant non-oncological disease considered by the investigator to be incompatible with the protocol
* Women and men who are sexually active and unwilling to use a medically acceptable method of contraception
* Treatment with other investigational drugs or participation in another clinical trial within the past four weeks before start of therapy or concomitantly with this trial (except for present trial drug)
* Patients unable to comply with the protocol
* Active alcohol or drug abuse