Clinical trial · Interventional
RCT: WLE vs. NBI in Upper Gastrointestinal Endoscopy
A Randomized Comparison Between White Light Endoscopy (WLE) and Bright Narrow Band Imaging (B-NBI) in Subjects Undergoing Upper Gastrointestinal Endoscopy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is recognized that gastroscopy can miss intestinal metaplasia, dysplasia and early gastric cancer. This could conceivably be due to the fact that these lesions may only present as subtle mucosal changes on conventional white light endoscopy (WLE) and thus be easily missed. In narrow band imaging (NBI) a rotating interference narrow band filter is interposed after the xenon light source such that when the NBI mode is switched on, discrete blue and green wavelengths are used and this improves mucosal surface contrast and facilitates visualization of mucosal details. A new NBI system is available that allows brighter illumination. We hypothesize that bright -NBI is superior to WLE in detecting focal gastric lesions such as gastric intestinal metaplasia, dysplasia and early gastric cancer in subjects undergoing gastroscopy.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Intestinal Metaplasia | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| narrow band imaging | Device | — | UNRESOLVED |
| white light endoscopy | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- white light endoscopy
- description
- white light endoscopy
- type
- ACTIVE_COMPARATOR
- label
- narrow band imaging
- description
- narrow band imaging
- interventionNames
- Device: narrow band imaging
- Device: white light endoscopy
Primary outcomes (1)
- measure
- Detection rate of intestinal metaplasia
- timeFrame
- At the point of gastroscopy
- description
- Detection rate of intestinal metaplasia by white light endoscopy and by narrow band imaging
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: 1. Subjects aged \> 50 years undergoing diagnostic or screening upper GI endoscopy 2. ability to provide a written consent to trial participation. Exclusion Criteria: 1. presence of active gastrointestinal bleeding 2. presence of coagulopathy precluding biopsies 3. absence of informed consent.
References
Publications (0)
Data not yet available