Clinical trial · Observational
Boramae Hospital Liver Cirrhosis Patient Cohort Study
Prospective Cohort Study to Evaluate Long-term Outcomes in Patients With Liver Cirrhosis of Boramae Hospital
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Liver cirrhosis represents a worldwide health problem and is a major cause of mortality. Cirrhosis is the common end for chronic alcohol abuse and hepatitis C and B virus infections. Patients who have cirrhosis have varying degrees of compensated liver function, and clinicians need to differentiate between those who have stable, compensated cirrhosis and those who have decompensated cirrhosis. It is shown various complications: portal hypertension, hepatocellular carcinoma, hepato-renal syndrome, etc. Thus, it is important to have this information to manage disease and determine specific therapy. However, register-based studies in have not been reported in Korea. The goal of this study is to describe the natural history of a large number of patients with liver cirrhosis prospectively followed, and to identify predictors of the occurrence of Hepatocellular carcinoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Cirrhosis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hepatic venous pressure gradient (HVPG) measurement | Device | — | UNRESOLVED |
| Liver biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (7)
- label
- Alcohol
- description
- Alcoholic Liver Cirrhosis Participants will undergo liver biopsy. Participants will undergo hepatic venous pressure gradient measurement.
- interventionNames
- Procedure: Liver biopsy
- Device: Hepatic venous pressure gradient (HVPG) measurement
- label
- Hepatitis B virus
- description
- Hepatitis B virus (HBV) Liver Cirrhosis
- interventionNames
- Procedure: Liver biopsy
- Device: Hepatic venous pressure gradient (HVPG) measurement
- label
- Hepatitis C virus
- description
- Hepatitis C virus (HCV) Liver Cirrhosis
- interventionNames
- Procedure: Liver biopsy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥19years old Proven cirrhosis * No previous hepatocellular carcinoma (treated or not) * Signed informed consent Exclusion Criteria: * serious associated short-term life threatening disease (except associated HIV viral infection and the liver disease itself) * liver focal lesion suggestive of hepatocellular carcinoma * patient under guardianship * pregnant women * inability to regular monitoring, for whatever reason
References
Publications (4)
- BACKGROUNDDam Fialla A, Schaffalitzky de Muckadell OB, Touborg Lassen A. Incidence, etiology and mortality of cirrhosis: a population-based cohort study. Scand J Gastroenterol. 2012 Jun;47(6):702-9. doi: 10.3109/00365521.2012.661759. Epub 2012 Mar 19. PMID 22428859
- BACKGROUNDReiberger T, Ferlitsch A, Payer BA, Pinter M, Homoncik M, Peck-Radosavljevic M; Vienna Hepatic Hemodynamic Lab. Non-selective beta-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis. J Gastroenterol. 2012 May;47(5):561-8. doi: 10.1007/s00535-011-0517-4. Epub 2011 Dec 15. PMID 22170417
- DERIVEDCho Y, Choi YI, Oh S, Han J, Joo SK, Lee DH, Jung YJ, Kim BG, Lee KL, Kim W. Point shear wave elastography predicts fibrosis severity and steatohepatitis in alcohol-related liver disease. Hepatol Int. 2020 Mar;14(2):270-280. doi: 10.1007/s12072-019-10009-w. Epub 2019 Dec 19. PMID 31858403
- DERIVEDKim HY, So YH, Kim W, Ahn DW, Jung YJ, Woo H, Kim D, Kim MY, Baik SK. Non-invasive response prediction in prophylactic carvedilol therapy for cirrhotic patients with esophageal varices. J Hepatol. 2019 Mar;70(3):412-422. doi: 10.1016/j.jhep.2018.10.018. Epub 2018 Oct 31. PMID 30389550