Clinical trial · Observational
Presentations of Hyperandrogenic Phenotypes in Taiwanese Women
Clinical and Biochemical Presentations of Distinctive Types of Biochemical Hyperandrogenism in Premenopausal Taiwanese Women
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
STUDY QUESTION: Which of the four abnormally elevated androgen groups (total testosterone \[TT\], androstenedione \[A4\], free androgen index \[FAI\], or dehydroepiandrosterone-sulfate \[DHEA-S\]) present with an unfavorable metabolic and hormonal profile, appear to be more insulin-resistant and pose additional cardiovascular risk? SUMMARY ANSWER: Subjects with excess free androgen index tend to be obese and face the highest metabolic syndrome risk, adipocytokine alterations, insulin resistance (IR) and cardiovascular risk. The excess TT group presents with a marginal IR risk, while the excess A4 group has the highest antimüllerian hormone (AMH), and may counterbalance obesity; this group and the excess DHEA-S group have a favorable association with IR.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiovascular Disease. | — | UNRESOLVED | — |
| Hyperandrogenism, | — | UNRESOLVED | — |
| Insulin Resistance, | — | UNRESOLVED | — |
| Metabolic Syndrome, | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome, | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (5)
- label
- Controls
- description
- patients who have all androgens (TT, A4, FAI, and DHEA-S) lower than their cut-off values
- label
- Total Testosterone >= 2.39
- description
- Patients who have only total testosterone higher than its cut-off value; (TT) \>=2.39
- label
- Androstenedione >= 2.99
- description
- Patients who have only androstenedione higher than its cut-off value; (A4) \>=2.99
- label
- Free Androgen Index >= 6.53
- description
- Patients who have only free androgen index higher than its cut-off value; (FAI) \>=6.53
- label
- DHEAs >= 181.55
- description
- Patients who have only dehyroepiandrosterone sulfate higher than its cut-off value; (DHEA-S)\>=181.55
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 13 Years
- Maximum age
- 48 Years
Show eligibility criteria text
Inclusion Criteria: * Hyperandrogenic women who were classified into four groups: * Total testosterone (TT), * Androstenedione (A4), * Free androgen index (FAI), * and Dehydroepiandrosterone sulphate(DHEA-S). * According to abnormally elevated androgen measures each above its cut-off value, and non hyperandrogenic women (who had all androgens below their cut-off values) Exclusion Criteria: * None of the women studied had * Hypogonadotropic hypogondism, * Hyperprolactinemia, * Congenital adrenal hyperplasia, * Premature ovarian failure, * Androgen-secreting tumors, * Cushing's syndrome, * or any other endocrine or systemic disease that may affect the reproductive function, * or any disorders of the uterus (e.g. Asherman's syndrome and Mullerian genesis) and chromosomal anomalies (e.g. Turner's syndrome). * In addition, we excluded females who had * Experienced menarche less than three years preceding the study start, * or who had day 3 FSH \> 15 mIU/ml, as well as women with insufficient clinical/biochemical records, * and women with ovarian cysts or tumors in an ultrasonographic examination.
References
Publications (0)
Data not yet available