Retinoid 9cUAB30 in Preventing Cancer in Healthy Volunteers

Inclusion Criteria:

* Normal volunteers, either male or female
* Eastern Cooperative Oncology Group (ECOG) performance status =\< 1 or Karnofsky \>= 70%
* White blood cell (WBC) \>= 3000/mm\^3
* Platelets \>= 100,000/mm\^3
* Hemoglobin \> 10 g/dL
* Bilirubin =\< upper limit of institutional normal
* Aspartate aminotransferase (AST) =\< upper limit of institutional normal
* Creatinine within institutional normal limits
* Sodium, potassium, chloride, bicarbonate: all =\< upper limit of institutional normal
* Fasting triglycerides =\< 1.5 x upper limit of normal (ULN)
* Fasting cholesterol =\< 1.5 x ULN
* Participants must agree to discontinue all vitamin supplements while taking study medication and for thirty days past the last dose of study medication
* Heterosexual women and men must agree to use TWO effective forms of birth control for the duration of study participation and for 30 days following the last dose of study medication

  * Men must agree not to donate sperm during the study and for three months after receiving the last dose of study drug
  * The following persons are not considered to be able to father or bear children and therefore are eligible to participate without the use of concurrent birth control:

    * Female with bilateral oophorectomy and/or hysterectomy
    * Female with fallopian tubes cut, tied, or sealed
    * Female with sterilization implant (e.g. Adiana, Essure) placed \> 3 months prior to randomization
    * Female post-menopausal (\> 1 year since last menses)
    * Male with vasectomy \> 3 months prior to randomization
  * One of the following methods of birth control must be used by women of childbearing potential:

    * Combined oral contraceptive pill in continuous use for \> 30 days prior to study entry
    * Vaginal ring (e.g. NuvaRing) in continuous use for \> 30 days prior to study entry
    * Skin patch (e.g. Ortho Evra) in continuous use for \> 30 days prior to study entry
    * Injection (e.g. Depo-Provera, Noristerat) in continuous use for \> 30 days prior to study entry
    * Copper intrauterine device (IUD) (e.g. ParaGard)
  * Note: The following hormonal methods are NOT acceptable:

    * Low dose progesterone only oral contraceptive pill ("mini pills" e.g. Micronor, Nor-Q.D., Ovrette)
    * Norplant subdermal implant
    * Mirena Hormonal Implanted Uterine Device (IUD)
  * In addition to the above method of contraception, one of the following methods of contraception will ALSO be used for the duration of study participation and for 30 days following the last dose of study medication:

    * Diaphragm, cervical cap, or cervical shield with spermicide
    * Contraceptive sponge (e.g. Today Sponge)
    * Condom (male or female type) plus spermicide
* Females of child-bearing potential must have a negative pregnancy test within the current menstrual cycle and within 7 days before starting drug
* Participants must have the ability to understand, and the willingness to sign, a written informed consent document

Exclusion Criteria:

* Participants may not be taking medications that might interact with 9cUAB30
* Participants may not be taking lipid lowering agents
* Participants may not receive any other investigational agents within 30 days of enrollment nor during study participation
* Participants with a history of allergic reactions attributed to compounds of similar chemical or biologic composition of retinoids
* Participants with an uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Breastfeeding must be discontinued for the duration of study participation and for one month after the last dose of the study agent if the mother is treated with 9cUAB30
* Individuals known to be human immunodeficiency virus (HIV)-positive may not participate in this study
* Individuals with a history of cancer diagnosis or reoccurrence \< 5 years from study entry may not participate; however, individuals with a history of squamous or basal cell carcinoma of the skin \< 5 years from study entry will not be excluded from this study