Clinical trial · Interventional
A Trial of Two Electrosurgical Conizations: Histopathological Analysis of Excision Margins
Large Loop Excision of Transformation Zone Cone Versus Straight Wire Excision of Transformation Zone : Histopathological Analysis of Excision Margins
NCT01929993CI-TRIAL-00018635completedPhase 3Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this trial is to evaluate if Straight Wire Excision of the Transformation Zone (SWETZ) is superior to (Large Loop Excision of the Transformation Zone) LLETZ cone in reducing the incomplete excision of disease.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Intraepithelial Neoplasia | Cervical Intraepithelial Neoplasia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| LLETZ cone | Procedure | — | UNRESOLVED |
| SWETZ | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- SWETZ
- description
- Straight wire excision of transformation zone is an electrosurgical conization method, which uses a straight wire electrode.
- interventionNames
- Procedure: SWETZ
- type
- ACTIVE_COMPARATOR
- label
- LLETZ cone
- description
- LLETZ cone is a electrosurgical conization method, which is performed with a large loop electrode of 20 mm depth.
- interventionNames
- Procedure: LLETZ cone
Primary outcomes (1)
- measure
- The Prevalence of Incomplete Excision of Dysplasia at the Endocervical Excision Margin as Recognized Histologically.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Patients were eligible if the colposcopist decided that a cone biopsy was indicated. * Common indications for a cone biopsy included: * High-grade Squamous Intraepithelial Lesion in a type 3 transformation zone, * suspicion of micro-invasive or invasive carcinoma and * suspicion of glandular disease. Exclusion Criteria: * Patients were excluded if pregnancy, coagulation disorders and cervicitis were present or if they refused to participate in the study.
References
Publications (1)
- DERIVEDRussomano F, Tristao MA, Cortes R, de Camargo MJ. A comparison between type 3 excision of the transformation zone by straight wire excision of the transformation zone (SWETZ) and large loop excision of the transformation zone (LLETZ): a randomized study. BMC Womens Health. 2015;15:12. doi: 10.1186/s12905-015-0174-5. Epub 2015 Feb 18. PMID 25783647