Clinical trial · Observational
Study on the Interplay Between Twist1 and Other EMT Regulators Through microRNA-29 Family.
Observational Study on the Investigation of the Molecular Mechanism and Clinical Significance of the Interplay Between Twist1 and Other EMT Regulators Through microRNA-29 Family.
NCT01927354CI-TRIAL-00012081unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Investigation of the molecular mechanism and clinical significance of the interplay between Twist1 and other EMT regulators through microRNA-29 family.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head-and-Neck Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (1)
- label
- Head and neck cancer
- description
- Subjects who suffer from oral cancer. Collect a 0.5x0.5Cm2 tissue sample of the tumor during the surgery.
Primary outcomes (1)
- measure
- The interplay between Twist1 and other EMT regulators throigh microRNA-29 family
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Head and neck cancer Exclusion Criteria: * pregnant woman
References
Publications (51)
- BACKGROUNDDepartment of health, the Executive Yuan, R.O.C. Cancer Registry Annual Report in Taiwan area, 2007. Goldenberg D, Lee J, Koch WM, et al.
- BACKGROUNDGoldenberg D, Lee J, Koch WM, Kim MM, Trink B, Sidransky D, Moon CS. Habitual risk factors for head and neck cancer. Otolaryngol Head Neck Surg. 2004 Dec;131(6):986-93. doi: 10.1016/j.otohns.2004.02.035. PMID 15577802
- BACKGROUNDHaffty BG. Concurrent chemoradiation in the treatment of head and neck cancer. Hematol Oncol Clin North Am. 1999 Aug;13(4):719-42, vi-vii. doi: 10.1016/s0889-8588(05)70088-5. PMID 10494509
- BACKGROUNDGilbert J, Forastiere AA. Organ preservation trials for laryngeal cancer. Otolaryngol Clin North Am. 2002 Oct;35(5):1035-54, vi. doi: 10.1016/s0030-6665(02)00035-x. PMID 12587246
- BACKGROUNDFanucchi M, Khuri FR. Chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck. Semin Oncol. 2004 Dec;31(6):809-15. doi: 10.1053/j.seminoncol.2004.09.014. PMID 15599859
- BACKGROUNDPapadimitrakopoulou VA, Izzo J, Mao L, Keck J, Hamilton D, Shin DM, El-Naggar A, den Hollander P, Liu D, Hittelman WN, Hong WK. Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: role in response to chemoprevention and cancer development. Clin Cancer Res. 2001 Oct;7(10):3127-34. PMID 11595705
- BACKGROUNDFarrar M, Sandison A, Peston D, Gailani M. Immunocytochemical analysis of AE1/AE3, CK 14, Ki-67 and p53 expression in benign, premalignant and malignant oral tissue to establish putative markers for progression of oral carcinoma. Br J Biomed Sci. 2004;61(3):117-24. doi: 10.1080/09674845.2004.11732655. PMID 15462255
- BACKGROUNDGold KA, Lee HY, Kim ES. Targeted therapies in squamous cell carcinoma of the head and neck. Cancer. 2009 Mar 1;115(5):922-35. doi: 10.1002/cncr.24123.