Clinical trial · Interventional
Preoperative Pain Control in Liver Surgery Patients
A Randomized Placebo-Controlled Study of Whether Pre-operative Pregabalin 150 mg Will Improve Pain Control in Patients With Hepatocellular Carcinoma Undergoing Partial Hepatectomy
NCT01923948CI-TRIAL-00021573completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pregabalin 150mg or placebo are administered 1 hour preoperatively in patients undergoing partial hepatectomy. Postoperatively, patients receive morphine as rescue analgesic. Morphine consumption in the first 48 hours is documented. Postoperative pain is measured by the visual analogue scale (VAS) score.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Pain, Postoperative | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Placebo (for Pregabalin) | Drug | — | UNRESOLVED |
| Pregabalin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Pregabalin
- description
- Single, 150 mg pre-operative oral dose of Pregabalin
- interventionNames
- Drug: Pregabalin
- type
- PLACEBO_COMPARATOR
- label
- Sugar Pill
- description
- Single, placebo pre-operative dose
- interventionNames
- Drug: Placebo (for Pregabalin)
Primary outcomes (1)
- measure
- Postoperative Opioid Consumption
- timeFrame
- 48 hours
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing partial hepatectomy Exclusion Criteria: * contraindication against pregabalin * creatinine \> 2.0 mg/dl * GGT \>165, AST \>105, ALT \>135 * peptic Ulcus * haemorrhagic diathesis * angina pectoris, myocardial infarction * stroke * bronchial asthma * opioid abuse
References
Publications (0)
Data not yet available
No reference posted for this study.