Clinical trial · Interventional
Resistance Training and Protein Supplementation for Prostate Cancer Survivors
Exercise and Protein Supplementation for Prostate Cancer Survivors Receiving Androgen Deprivation Therapy
NCT01909440CI-TRIAL-00039144completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This randomized pilot clinical trial studies resistance training and protein supplementation in increasing lean body mass in patients with prostate cancer receiving androgen deprivation therapy. Resistance training and protein supplementation may help improve quality of life in patients with prostate cancer receiving androgen deprivation therapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| exercise intervention | Behavioral | — | UNRESOLVED |
| laboratory biomarker analysis | Other | — | UNRESOLVED |
| nutritional supplementation | Dietary Supplement | — | UNRESOLVED |
| pharmacological study | Other | — | UNRESOLVED |
| quality-of-life assessment | Procedure | — | UNRESOLVED |
| questionnaire administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Arm I (RT + PS)
- description
- Patients undergo total body high-intensity RT thrice weekly and perform static stretching exercises after each session. Exercises progress from low intensity and high volume to higher intensity and lower volume over the course of the 12-week program. Patients also receive whey protein supplementation orally twice a day for 12 weeks.
- interventionNames
- Behavioral: exercise intervention
- Dietary Supplement: nutritional supplementation
- Procedure: quality-of-life assessment
- Other: questionnaire administration
- Other: pharmacological study
- Other: laboratory biomarker analysis
- type
- EXPERIMENTAL
- label
- Arm II (total body RT)
- description
- Patients undergo total body RT and stretching as in Arm I.
- interventionNames
- Behavioral: exercise intervention
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosed with prostate cancer * Treatment with androgen deprivation therapy (ADT) (gonadotropin-releasing hormone \[GnRH\] agonist/antagonist with or without anti-androgen) for prostate cancer * Receiving ADT for a minimum of 12 weeks before enrollment into the study * Planned ADT for the duration of the 12-week study period * Asymptomatic, or minimally symptomatic from prostate cancer or prostate cancer related therapies * No opioid-requiring cancer related pain * Any therapy related genitourinary or gastrointestinal symptoms should be considered as mild (Common Terminology Criteria for Adverse Events \[CTCAE\] grade 1 or 2) and not interfering with activities of daily living * Permission from treating/study physician to participate in RT Exclusion Criteria: * No concurrent use of chemotherapy or radiotherapy (radiotherapy should be completed at least 4 weeks from study entry) * History of allergic reactions to whey protein * Milk protein intolerance/allergies (lactose intolerance is acceptable) * Subjects currently using N-acetylcysteine, alpha-lipoic acid supplements, or dry whey protein supplements * Recovered from major surgery within the last 6 months * Acute coronary (e.g. myocardial infarction) or vascular event within the last year as well as uncontrolled coronary heart disease (e.g. progressive angina) * Stroke within the past 2 years * Neurologic and/or orthopedic limitations that preclude the participation in the training program (e.g. bone metastases that may pose a high risk of pathologic fracture) * Subjects currently participating in a RT program
References
Publications (3)
- DERIVEDDawson JK, Dorff TB, Tuzon C, Rice JC, Schroeder ET, Lane CJ, Gross ME, Dieli-Conwright CM. Effect of Periodized Resistance Training on Skeletal Muscle During Androgen Deprivation Therapy for Prostate Cancer: A Pilot Randomized Trial. Integr Cancer Ther. 2021 Jan-Dec;20:15347354211035442. doi: 10.1177/15347354211035442. PMID 34301165
- DERIVEDDawson JK, Dorff TB, Todd Schroeder E, Lane CJ, Gross ME, Dieli-Conwright CM. Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial. BMC Cancer. 2018 Apr 3;18(1):368. doi: 10.1186/s12885-018-4306-9. PMID 29614993
- DERIVEDKiwata JL, Dorff TB, Todd Schroeder E, Salem GJ, Lane CJ, Rice JC, Gross ME, Dieli-Conwright CM. A pilot randomised controlled trial of a periodised resistance training and protein supplementation intervention in prostate cancer survivors on androgen deprivation therapy. BMJ Open. 2017 Jul 10;7(7):e016910. doi: 10.1136/bmjopen-2017-016910. PMID 28698349