Cardiac Fibrosis by CMR in Patients With Cancer

A study to test the effectiveness of an investigational imaging technique for detecting cardiac injury after the administration of certain chemotherapies, such as doxorubicin. "Investigational" means that the imaging technique is still being studied and that research doctors are trying to find out more about it- such as whether the technique can detect lower levels of cardiac injury after treatment with doxorubicin. It also means that the FDA (the U.S. Food and Drug Administration) has not yet approved the use of gadolinium or approved the use of CMR studies for detection of cardiac toxicity after doxorubicin. The chemotherapy drug that you have been scheduled to be treated with, doxorubicin, has been associated with the development of heart failure in some patients. Cardiac Magnetic Resonance (CMR) is a type of MRI scan that uses a magnetic field to produce pictures of the heart. The CMR scan has been used in other studies and information from those other research studies suggest that this imaging technique may help to better detect differences in the structure of the heart muscle after treatment with doxorubicin. In this research study, we hope that we can better detect changes in the heart muscle after treatment with doxorubicin with a CMR scan in the hopes that cardiac injury can be detected and treated earlier to ultimately prevent the possible development of heart failure

Sex

All

Minimum age

18 Years

Inclusion Criteria:

* Aged ≥ 18 and able to give consent
* New diagnosis of lymphoma and scheduled to undergo doxorubicin (DOX)-based chemotherapy.

Exclusion Criteria:

* Concurrent radiotherapy prior to the performance of both CMR studies, however consolidative radiotherapy after the completion of DOX and after the acquisition of the second CMR study is acceptable
* No prior malignancy treated with chemotherapy or mediastinal radiotherapy
* No contraindications to the performance of a magnetic resonance study:
* The presence of an implanted metallic object such as a cardiac pacemaker or implantable defibrillator
* An implanted neural stimulator
* Any ferromagnetic implants not deemed MRI-safe
* Intra-ocular metallic foreign bodies
* Severe claustrophobia
* Pregnancy
* Inability to perform an exercise test
* Glomerular filtration rate \< 60 ml/min/1.73 m2